Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 5/20 | 0.59 |
| ▸ | LMNA | P02545 | 2/20 | 0.56 |
| ▸ | POLB | P06746 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21315846 | 1.00 | SIGMAR1 (0.59) | SIGMAR1LMNAPOLBALDH1A1MEN1 | |
| SCHEMBL30662448 | 0.87 | SIGMAR1 (0.56) | SIGMAR1LMNAPOLBALDH1A1MEN1 | |
| SCHEMBL3343632 | 0.85 | SIGMAR1 (0.58) | SIGMAR1LMNAPOLBALDH1A1MEN1 | |
| SCHEMBL65364 | 0.85 | SIGMAR1 (0.78) | SIGMAR1LMNAPOLBALDH1A1MEN1 | |
| SCHEMBL20719 | 0.85 | SIGMAR1 (0.78) | SIGMAR1LMNAPOLBALDH1A1MEN1 | |
| SCHEMBL5562968 | 0.85 | SIGMAR1 (0.61) | SIGMAR1LMNAPOLBALDH1A1 | |
| SCHEMBL7240012 | 0.85 | SIGMAR1 (0.58) | SIGMAR1LMNAPOLBALDH1A1MEN1 | |
| SCHEMBL2458948 | 0.85 | LMNA (0.59) | SIGMAR1LMNAPOLBALDH1A1MEN1 | |
| SCHEMBL3317019 | 0.85 | LMNA (0.59) | SIGMAR1LMNAPOLBALDH1A1MEN1 | |
| SCHEMBL5561055 | 0.85 | SIGMAR1 (0.61) | SIGMAR1LMNAPOLBALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 104 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240216361-A1 | ROR-GAMMA MODULATORS | ESCALIER BIOSCIENCES B V (US) | 2024-07-04 | — | — | US | disclosed |
| US-20230277527-A1 | ROR-GAMMA MODULATORS | ESCALIER BIOSCIENCES B.V. | 2023-09-07 | — | — | US | disclosed |
| CN-110139652-B | ROR-gamma modulators | 爱思凯利尔生物科学私人有限责任公司 | 2022-10-11 | — | — | CN | disclosed |
| EP-3532062-B1 | ROR-GAMMA MODULATORS | ESCALIER BIOSCIENCES BV (US) | 2022-07-20 | — | — | EP | disclosed |
| US-20220175765-A1 | ROR-GAMMA MODULATORS | ESCALIER BIOSCIENCES B.V. | 2022-06-09 | — | — | US | disclosed |
| US-20210069182-A1 | ROR-GAMMA MODULATORS | ESCALIER BIOSCIENCES B.V. | 2021-03-11 | — | — | US | disclosed |
| US-10905687-B2 | Substituted piperazines as ROR-gamma modulators | ESCALIER BIOSCIENCES B.V. (US) | 2021-02-02 | — | — | US | disclosed |
| EP-2900666-B1 | AZAQUINAZOLINE INHIBITORS OF ATYPICAL PROTEIN KINASE C | CANCER RESEARCH TECH LTD (GB) | 2020-11-04 | — | — | EP | disclosed |
| US-20190269674-A1 | ROR-GAMMA MODULATORS | ESCALIER BIOSCIENCES, BV (US) | 2019-09-05 | — | — | US | disclosed |
| EP-3532062-A1 | ROR-GAMMA MODULATORS | Escalier Biosciences, BV (US) | 2019-09-04 | — | — | EP | disclosed |
| EP-0288519-A4 | 1-TERTIARY-ALKYL-SUBSTITUTED NAPHTHYRIDINE- AND QUINOLINE-CARBOXYLIC ACID ANTIBACTERIAL AGENTS | — | 1992-04-15 | — | — | EP | disclosed |
| US-5017573-A | Serotonin receptor antagonist | DAINIPPON PHARMACEUTICAL CO., LTD. (JP) | 1991-05-21 | — | — | US | disclosed |
| US-4965273-A | Certain 1-tertiary-butyl-naphthyridone carboxylic acid derivatives anti-bacterial agents | BRISTOL-MYERS COMPANY (US) | 1990-10-23 | — | — | US | disclosed |
| US-4954507-A | 1-tertiary-alkyl-substituted naphthyridine carboxylic acid antibacterial agents | BRISTOL-MYERS COMPANY (US) | 1990-09-04 | — | — | US | disclosed |
| US-4940710-A | 7-(substituted)piperazinyl-1-ethyl-6-fluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acids | AMERICAN CYANAMID COMPANY (US) | 1990-07-10 | — | — | US | disclosed |
| EP-0358903-A2 | Indazole-3-carboxylic acid derivatives | DAINIPPON PHARMACEUTICAL CO., LTD. (JP) | 1990-03-21 | — | — | EP | disclosed |
| EP-0288519-A1 | 1-TERTIARY-ALKYL-SUBSTITUTED NAPHTHYRIDINE- AND QUINOLINE-CARBOXYLIC ACID ANTIBACTERIAL AGENTS | Bristol-Myers Squibb Company (US) | 1988-11-02 | — | — | EP | disclosed |
| EP-0266576-A2 | 1-Tert-alkyl-substituted naphthyridine and quinoline carboxylic acids as antibacterial agents | Bristol-Myers Squibb Company (US) | 1988-05-11 | — | — | EP | disclosed |
| WO-1988002627-A1 | 1-TERTIARY-ALKYL-SUBSTITUTED NAPHTHYRIDINE- AND QUINOLINE-CARBOXYLIC ACID ANTIBACTERIAL AGENTS | BRISTOL-MYERS COMPANY (US) | 1988-04-21 | — | — | WO | disclosed |
| EP-0230053-A2 | 7-(Substituted)piperazinyl-1-ethyl-6-fluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acids | AMERICAN CYANAMID COMPANY (US) | 1987-07-29 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230277527-A1 | ROR-GAMMA MODULATORS | RORB, RORC, RORA | SIGMAR1 1215/4885LMNA 2990/4885POLB 2301/4885 |
| US-20240216361-A1 | ROR-GAMMA MODULATORS | RORB, RORC, RORA | SIGMAR1 1215/4885LMNA 2990/4885POLB 2301/4885 |
| US-20210069182-A1 | ROR-GAMMA MODULATORS | RORB, RORC, RORA | SIGMAR1 1215/4885LMNA 2990/4885POLB 2301/4885 |
| US-10905687-B2 | Substituted piperazines as ROR-gamma modulators | RORC, RORA, RORB | SIGMAR1 477/4885LMNA 2539/4885POLB 1965/4885 |
| US-20220175765-A1 | ROR-GAMMA MODULATORS | RORB, RORC, RORA | SIGMAR1 1215/4885LMNA 2990/4885POLB 2301/4885 |
| US-20190269674-A1 | ROR-GAMMA MODULATORS | RORB, RORC, RORA | SIGMAR1 1215/4885LMNA 2990/4885POLB 2301/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.