Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | PKM | P14618 | 1/20 | 0.49 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.47 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.47 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | ADRB1 | P08588 | 2/20 | 0.42 |
| ▸ | NPC1 | O15118 | 2/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | CACNA1A | O00555 | 1/20 | 0.41 |
| ▸ | CACNA2D1 | P54289 | 1/20 | 0.41 |
| ▸ | CACNB1 | Q02641 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7376264 | 0.87 | LGMN (0.40) | MAPTPKMALDH1A1RAB9AKMT2A | |
| SCHEMBL5388810 | 0.87 | ALDH1A1 (0.42) | MAPTPKMALDH1A1SMN1; SMN2MEN1 | |
| SCHEMBL5922625 | 0.87 | ALDH1A1 (0.46) | MAPTSLC6A4ALDH1A1ADRB1SMN1; SMN2 | |
| SCHEMBL10589809 | 0.86 | SLC6A2 (0.52) | SLC6A2SLC6A4SLC6A3NPC1RAB9A | |
| SCHEMBL16731889 | 0.85 | SLC6A4 (0.47) | SLC6A2SLC6A4SLC6A3ALDH1A1ADRB1 | |
| SCHEMBL21360310 | 0.85 | SLC6A4 (0.47) | SLC6A2SLC6A4SLC6A3ALDH1A1ADRB1 | |
| SCHEMBL5389244 | 0.84 | ALDH1A1 (0.51) | SLC6A2SLC6A4SLC6A3ALDH1A1SMN1; SMN2 | |
| SCHEMBL27529782 | 0.83 | SLC6A4 (0.53) | SLC6A2SLC6A4SLC6A3ALDH1A1ADRB1 | |
| SCHEMBL27561229 | 0.82 | SLC6A2 (0.44) | SLC6A2SLC6A4SLC6A3ALDH1A1ADRB1 | |
| SCHEMBL9396845 | 0.80 | SLC6A2 (0.53) | SLC6A2SLC6A4SLC6A3ALDH1A1ADRB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0638568-B1 | Substituted piperazines, their process of preparation and the pharmaceutical compositions containing them | ADIR (FR) | 1996-10-09 | — | — | EP | disclosed |
| EP-0703908-A1 | ANALGESIC DIBENZOXAZEPINES AND DIBENZOTHIAZEPINES | G.D. SEARLE & CO. (US) | 1996-04-03 | — | — | EP | disclosed |
| US-5500426-A | ADMINISTERED TO IMPROVE GLUCOSE TOLERANCE | ADIR ET COMPAGNIE (FR) | 1996-03-19 | — | — | US | disclosed |
| US-5492912-A | IMPROVES GLUCOSE TOLERANCE | ADIR ET COMPAGNIE (FR) | 1996-02-20 | — | — | US | disclosed |
| US-5461047-A | Analgesics and treats prostaglandin-E2 mediated diseases in animals | G. D. SEARLE & CO. (US) | 1995-10-24 | — | — | US | disclosed |
| EP-0638568-A1 | Substituted piperazines, their process of preparation and the pharmaceutical compositions containing them | ADIR ET COMPAGNIE (FR) | 1995-02-15 | — | — | EP | disclosed |
| WO-1994029286-A1 | ANALGESIC DIBENZOXAZEPINES AND DIBENZOTHIAZEPINES | G.D. SEARLE & CO. (US) | 1994-12-22 | — | — | WO | disclosed |
| WO-1994027981-A1 | SQUARIC ACID DERIVATIVES OF DIBENZOXAZEPINS OR DIBENZOTHIAZEPINES USEFUL AS ANALGESICS | G.D. SEARLE & CO. (US) | 1994-12-08 | — | — | WO | disclosed |
| US-5354747-A | Analgesics | G. D. SEARLE & CO. (US) | 1994-10-11 | — | — | US | disclosed |
| US-5354746-A | Prostaglandin inhibitor, analgesics | G. D. SEARLE & CO. (US) | 1994-10-11 | — | — | US | disclosed |