Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | NPC1 | O15118 | 5/20 | 0.46 |
| ▸ | RAB9A | P51151 | 5/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.46 |
| ▸ | HPGD | P15428 | 3/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.44 |
| ▸ | CASP3 | P42574 | 1/20 | 0.41 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.41 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.41 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | MAOA | P21397 | 1/20 | 0.38 |
| ▸ | PDE7A | Q13946 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8945962 | 0.83 | ALDH1A1 (0.46) | LMNANPC1RAB9ASMN1; SMN2HPGD | |
| SCHEMBL8946180 | 0.82 | PARP14 (0.47) | GSK3BLMNANPC1RAB9ASMN1; SMN2 | |
| SCHEMBL8945794 | 0.82 | KMT2A (0.53) | GSK3BLMNANPC1RAB9ASMN1; SMN2 | |
| SCHEMBL3014357 | 0.76 | NPC1 (0.51) | LMNANPC1RAB9ASMN1; SMN2HPGD | |
| SCHEMBL6973314 | 0.74 | NPC1 (0.50) | LMNANPC1RAB9ASMN1; SMN2HPGD | |
| SCHEMBL442788 | 0.74 | CYP1A2 (0.69) | LMNANPC1RAB9ASMN1; SMN2HPGD | |
| SCHEMBL9452749 | 0.74 | CYP1A2 (0.69) | LMNANPC1RAB9ASMN1; SMN2HPGD | |
| SCHEMBL11329796 | 0.74 | NPC1 (0.52) | LMNANPC1RAB9ASMN1; SMN2HPGD | |
| SCHEMBL9651528 | 0.74 | MAOA (0.59) | LMNANPC1RAB9ASMN1; SMN2HPGD | |
| SCHEMBL9726169 | 0.73 | NPC1 (0.51) | LMNANPC1RAB9ASMN1; SMN2HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5510346-A | ANTIDEPRESSANTS, ANTIANXIETY AGENTS | HOECHST MARION ROUSSEL, INC. (US) | 1996-04-23 | — | — | US | disclosed |
| US-5292760-A | 4-heteroaryl-1,3-benzodiazepines and 2-substituted-α-(heteroaryl)benzeneethanamines | HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) | 1994-03-08 | — | — | US | disclosed |