Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 1/20 | 0.39 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8946088 | 0.89 | ALOX5 (0.41) | ALOX5OPRK1KMT2AKDM4EALDH1A1 | |
| SCHEMBL8760175 | 0.88 | OPRK1 (0.39) | ALOX5OPRK1KMT2A | |
| Hydrochloric Acid SCHEMBL8760208 | 0.87 | OPRK1 (0.38) | ALOX5OPRK1KMT2A | |
| SCHEMBL8945876 | 0.84 | ALOX5 (0.35) | ALOX5KMT2A | |
| SCHEMBL8945840 | 0.81 | ALOX5 (0.35) | ALOX5KMT2AALDH1A1 | |
| SCHEMBL8761049 | 0.79 | ALOX5 (0.36) | ALOX5KMT2AALDH1A1 | |
| SCHEMBL8945832 | 0.77 | ALOX5 (0.38) | ALOX5OPRK1KDM4EALDH1A1HPGD | |
| SCHEMBL9425163 | 0.74 | ALOX5 (0.35) | ALOX5KMT2A | |
| Maleic Acid SCHEMBL8761537 | 0.74 | ALOX5 (0.33) | ALOX5OPRK1KMT2A | |
| Fumaric Acid SCHEMBL8761550 | 0.74 | ALOX5 (0.33) | ALOX5OPRK1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5292760-A | 4-heteroaryl-1,3-benzodiazepines and 2-substituted-α-(heteroaryl)benzeneethanamines | HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) | 1994-03-08 | — | — | US | claimed |
| US-5510346-A | ANTIDEPRESSANTS, ANTIANXIETY AGENTS | HOECHST MARION ROUSSEL, INC. (US) | 1996-04-23 | — | — | US | disclosed |
| US-5292760-A | 4-heteroaryl-1,3-benzodiazepines and 2-substituted-α-(heteroaryl)benzeneethanamines | HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) | 1994-03-08 | — | — | US | disclosed |
| EP-0322582-A2 | 4-Heteroaryl-1,3-Benzodiazepines and 2-substituted-alpha-(heteroaryl)benzeneethanamines, a process for their preparation and their use us medicaments | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1989-07-05 | — | — | EP | disclosed |