SCHEMBL8946144

SCHEMBL8946144

CCC1=Nc2ccccc2CC(c2ccncc2)N1C

nearest known ligand 0.34

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
CYP19A1 P11511 3/20 0.34
DRD2 P14416 1/20 0.32
HRH4 Q9H3N8 1/20 0.32
MAOA P21397 3/20 0.32
MAOB P27338 3/20 0.32
KMT2A Q03164 1/20 0.32
CYP2D6 P10635 1/20 0.31
RECQL P46063 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Water SCHEMBL8945782 0.99 CYP19A1 (0.33) CYP19A1DRD2HRH4MAOAMAOB
Water SCHEMBL8945777 0.99 CYP19A1 (0.33) CYP19A1DRD2HRH4MAOAMAOB
SCHEMBL11270824 0.91 CHRNB2 (0.37) MAOAMAOBKMT2ACYP2D6RECQL
SCHEMBL9583461 0.87 MAOA (0.40) MAOAMAOBKMT2A
SCHEMBL8945919 0.86 CHRNB2 (0.45) KMT2A
SCHEMBL11272153 0.86 ALDH1A1 (0.39) MAOAMAOB
SCHEMBL9584219 0.86 MAOB (0.41) DRD2MAOAMAOBKMT2A
SCHEMBL9582044 0.86 NPY1R (0.36) KMT2ARECQL
SCHEMBL9582906 0.86 MAOB (0.41) MAOAMAOB
Hydrochloric Acid SCHEMBL9582514 0.85 ALDH1A1 (0.38) MAOAMAOB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5510346-A ANTIDEPRESSANTS, ANTIANXIETY AGENTS HOECHST MARION ROUSSEL, INC. (US) 1996-04-23 US claimed