Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 | P23975 | 3/20 | 0.56 |
| ▸ | BCHE | P06276 | 3/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | CYP11B1 | P15538 | 3/20 | 0.38 |
| ▸ | CYP11B2 | P19099 | 3/20 | 0.38 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.38 |
| ▸ | HTR2C | P28335 | 1/20 | 0.36 |
| ▸ | MAOA | P21397 | 1/20 | 0.35 |
| ▸ | MAOB | P27338 | 1/20 | 0.35 |
| ▸ | ORAI1 | Q96D31 | 1/20 | 0.35 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.35 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8946101 | 0.86 | BCHE (0.42) | SLC6A2BCHEMAPTCYP11B1CYP11B2 | |
| SCHEMBL8946156 | 0.81 | SLC6A2 (0.49) | SLC6A2BCHEMAPT | |
| SCHEMBL8539324 | 0.78 | BCHE (0.72) | SLC6A2BCHEMAOAMAOB | |
| SCHEMBL8546204 | 0.78 | SLC6A2 (0.50) | SLC6A2BCHEMAPT | |
| SCHEMBL8946196 | 0.78 | SLC6A2 (0.42) | SLC6A2BCHEMAPTROCK1 | |
| Hydrochloric Acid SCHEMBL8539619 | 0.77 | SLC6A2 (0.49) | SLC6A2BCHEMAPT | |
| SCHEMBL7621050 | 0.77 | BCHE (0.51) | SLC6A2BCHEROCK1 | |
| Hydrochloric Acid SCHEMBL8544417 | 0.76 | BCHE (0.51) | SLC6A2BCHEROCK1 | |
| SCHEMBL9738839 | 0.76 | BCHE (0.75) | SLC6A2BCHE | |
| Hydrochloric Acid SCHEMBL9671984 | 0.75 | BCHE (0.74) | SLC6A2BCHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0509400-B1 | 1-(Pyrido[3,4-b]-1,4-oxazinyl-4-yl)-1H-indoles, intermediates and a process for their preparation, and their use as medicaments | HOECHST ROUSSEL PHARMA (US) | 1996-07-03 | — | — | EP | disclosed |
| US-5519131-A | CYCLIZATION OF HYDROXYALKYLAMINO COMPOUND IN THE PRESENCE OF STRONG BASE SUCH AS SODIUM HYDRIDE OR POTASSIUM TERT-BUTOXIDE | HOECHST MARION ROUSSEL INC. (US) | 1996-05-21 | — | — | US | disclosed |
| US-5276156-A | Antidepressants, treatment of Alzheimer*s disease | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1994-01-04 | — | — | US | disclosed |
| US-5214038-A | Cholinesterase inhibitors, antidepressants, cognition activators | HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) | 1993-05-25 | — | — | US | disclosed |
| EP-0509400-A1 | 1-(Pyrido[3,4-b]-1,4-oxazinyl-4-yl)-1H-indoles, intermediates and a process for their preparation, and their use as medicaments | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1992-10-21 | — | — | EP | disclosed |