SCHEMBL8946290

SCHEMBL8946290

CNc1cc(C(=O)OC)nc2cc(Cl)cc(Cl)c12

nearest known ligand 0.53

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
NQO2 P16083 9/20 0.53
MAOA P21397 1/20 0.42
ACHE P22303 1/20 0.42
MRGPRX4 Q96LA9 1/20 0.38
KDM4E B2RXH2 2/20 0.36
POLB P06746 1/20 0.36
ATM Q13315 1/20 0.36
ALDH1A1 P00352 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8946246 0.87 CYP1A2 (0.42) NQO2ALDH1A1
SCHEMBL8946276 0.86 ACHE (0.40) NQO2ACHE
SCHEMBL8946339 0.83 ESR1 (0.42) NQO2KDM4EPOLBALDH1A1
SCHEMBL8946957 0.83 NQO2 (0.39) NQO2KDM4EATMALDH1A1
SCHEMBL9462823 0.83 NQO2 (0.75) NQO2MRGPRX4KDM4E
SCHEMBL2905353 0.83 NQO2 (0.56) NQO2MRGPRX4KDM4EALDH1A1
SCHEMBL8946324 0.82 NQO2 (0.61) NQO2MRGPRX4KDM4EALDH1A1
SCHEMBL9463012 0.81 NQO2 (0.64) NQO2MRGPRX4KDM4EALDH1A1
SCHEMBL9462760 0.81 NQO2 (0.64) NQO2KDM4E
SCHEMBL9462812 0.75 NQO2 (0.64) NQO2KDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5493027-A ANTIEPILEPTIC AGENTS, NEUROGENATIVE DISEASES BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) 1996-02-20 US disclosed