Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA2A | P08913 | 1/20 | 0.37 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.37 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.37 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.37 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.35 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.35 |
| ▸ | ATM | Q13315 | 1/20 | 0.35 |
| ▸ | HTR2A | P28223 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8946458 | 1.00 | ADRA2A (0.37) | ADRA2AADRA2BADRA2CADRA1BPDK2 | |
| SCHEMBL8946453 | 1.00 | ADRA2A (0.37) | ADRA2AADRA2BADRA2CADRA1BPDK2 | |
| SCHEMBL8946527 | 0.84 | CYP1A2 (0.33) | ADRA2AADRA2BADRA2CADRA1BGAA | |
| SCHEMBL8946532 | 0.84 | CYP1A2 (0.33) | ADRA2AADRA2BADRA2CADRA1BGAA | |
| SCHEMBL8946536 | 0.84 | CYP1A2 (0.33) | ADRA2AADRA2BADRA2CADRA1BGAA | |
| SCHEMBL10382345 | 0.82 | CYP3A4 (0.32) | — | |
| SCHEMBL8946411 | 0.81 | HPGD (0.44) | ADRA2AADRA2BADRA2CADRA1BPDK2 | |
| SCHEMBL8946416 | 0.81 | HPGD (0.44) | ADRA2AADRA2BADRA2CADRA1BPDK2 | |
| SCHEMBL8946424 | 0.81 | HPGD (0.44) | ADRA2AADRA2BADRA2CADRA1BPDK2 | |
| SCHEMBL8946427 | 0.73 | KMT2A (0.33) | ADRA2AADRA2BADRA2CADRA1BPDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0409410-B1 | Indenoindole compounds | UNIV BATH (GB) | 1996-03-20 | — | — | EP | claimed |
| US-5516788-A | TREATMENT OF ATHEROSCLEROSIS; ANTIISCHEMIC, ANTICARCINOGENIC AGENTS; ANTICOAGULANTS | UNIVERSITY OF BATH (GB) | 1996-05-14 | — | — | US | disclosed |
| EP-0409410-B1 | Indenoindole compounds | UNIV BATH (GB) | 1996-03-20 | — | — | EP | disclosed |
| EP-0481708-A1 | Indenoindole compounds | UNIVERSITY OF BATH (GB) | 1992-04-22 | — | — | EP | disclosed |
| EP-0409410-A1 | Indenoindole compounds | UNIVERSITY OF BATH (GB) | 1991-01-23 | — | — | EP | disclosed |
| WO-1990015799-A1 | INDENOINDOLE COMPOUNDS II | UNIVERSITY OF BATH (GB) | 1990-12-27 | — | — | WO | disclosed |