Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 2/20 | 0.44 |
| ▸ | GFER | P55789 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.34 |
| ▸ | HTT | P42858 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | XBP1 | P17861 | 1/20 | 0.34 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | KIF11 | P52732 | 2/20 | 0.31 |
| ▸ | AKR1B1 | P15121 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8946411 | 1.00 | HPGD (0.44) | HPGDGFERHSD17B10PDK2ALDH1A1 | |
| SCHEMBL8946424 | 1.00 | HPGD (0.44) | HPGDGFERHSD17B10PDK2ALDH1A1 | |
| SCHEMBL8946536 | 0.82 | CYP1A2 (0.33) | HPGDHSD17B10ALDH1A1MAPTKDM4E | |
| SCHEMBL8946532 | 0.82 | CYP1A2 (0.33) | HPGDHSD17B10ALDH1A1MAPTKDM4E | |
| SCHEMBL8946527 | 0.82 | CYP1A2 (0.33) | HPGDHSD17B10ALDH1A1MAPTKDM4E | |
| SCHEMBL8946458 | 0.81 | ADRA2A (0.37) | PDK2ADRA2AADRA2BADRA2CADRA1B | |
| SCHEMBL8946404 | 0.81 | ADRA2A (0.37) | PDK2ADRA2AADRA2BADRA2CADRA1B | |
| SCHEMBL8946453 | 0.81 | ADRA2A (0.37) | PDK2ADRA2AADRA2BADRA2CADRA1B | |
| SCHEMBL26088084 | 0.69 | HPGD (0.41) | HPGDGFERHSD17B10PDK2ALDH1A1 | |
| SCHEMBL8946432 | 0.67 | KMT2A (0.33) | PDK2KMT2AADRA2AADRA2BADRA2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0409410-B1 | Indenoindole compounds | UNIV BATH (GB) | 1996-03-20 | — | — | EP | claimed |
| EP-0409410-A1 | Indenoindole compounds | UNIVERSITY OF BATH (GB) | 1991-01-23 | — | — | EP | claimed |
| US-5516788-A | TREATMENT OF ATHEROSCLEROSIS; ANTIISCHEMIC, ANTICARCINOGENIC AGENTS; ANTICOAGULANTS | UNIVERSITY OF BATH (GB) | 1996-05-14 | — | — | US | disclosed |
| EP-0409410-B1 | Indenoindole compounds | UNIV BATH (GB) | 1996-03-20 | — | — | EP | disclosed |
| EP-0409410-A1 | Indenoindole compounds | UNIVERSITY OF BATH (GB) | 1991-01-23 | — | — | EP | disclosed |