Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 4/20 | 0.38 |
| ▸ | HRH1 | P35367 | 2/20 | 0.36 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.36 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.36 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.36 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.36 |
| ▸ | HTR2A | P28223 | 1/20 | 0.36 |
| ▸ | HTR2C | P28335 | 1/20 | 0.36 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.36 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.36 |
| ▸ | HTR2B | P41595 | 1/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
| ▸ | PRCP | P42785 | 2/20 | 0.35 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.34 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8946449 | 1.00 | SIGMAR1 (0.38) | SIGMAR1HRH1ADRA2AADRA2BADRA2C | |
| SCHEMBL8946443 | 1.00 | SIGMAR1 (0.38) | SIGMAR1HRH1ADRA2AADRA2BADRA2C | |
| SCHEMBL8946337 | 0.81 | AVPR2 (0.33) | SIGMAR1 | |
| SCHEMBL8946326 | 0.81 | AVPR2 (0.33) | SIGMAR1 | |
| SCHEMBL8946880 | 0.80 | PRCP (0.48) | SIGMAR1ADRA1APRCP | |
| SCHEMBL8946747 | 0.78 | ADRA2A (0.41) | HRH1ADRA2AADRA2BADRA2CSLC6A2 | |
| SCHEMBL8946743 | 0.78 | ADRA2A (0.41) | HRH1ADRA2AADRA2BADRA2CSLC6A2 | |
| SCHEMBL8946720 | 0.78 | ADRA2A (0.41) | HRH1ADRA2AADRA2BADRA2CSLC6A2 | |
| SCHEMBL21152712 | 0.77 | SIGMAR1 (0.42) | SIGMAR1 | |
| SCHEMBL11359103 | 0.70 | HRH1 (0.58) | HRH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5516788-A | TREATMENT OF ATHEROSCLEROSIS; ANTIISCHEMIC, ANTICARCINOGENIC AGENTS; ANTICOAGULANTS | UNIVERSITY OF BATH (GB) | 1996-05-14 | — | — | US | disclosed |
| EP-0409410-B1 | Indenoindole compounds | UNIV BATH (GB) | 1996-03-20 | — | — | EP | disclosed |
| EP-0409410-A1 | Indenoindole compounds | UNIVERSITY OF BATH (GB) | 1991-01-23 | — | — | EP | disclosed |
| WO-1990015799-A1 | INDENOINDOLE COMPOUNDS II | UNIVERSITY OF BATH (GB) | 1990-12-27 | — | — | WO | disclosed |