Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.39 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 3/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.35 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8946917 | 1.00 | ALDH1A1 (0.40) | ALDH1A1KDM4EATMTP53LMNA | |
| SCHEMBL8946913 | 1.00 | ALDH1A1 (0.40) | ALDH1A1KDM4EATMTP53LMNA | |
| SCHEMBL8946423 | 0.85 | BACE1 (0.36) | ALDH1A1KDM4EATMTP53GAA | |
| SCHEMBL8946415 | 0.85 | BACE1 (0.36) | ALDH1A1KDM4EATMTP53GAA | |
| SCHEMBL8946412 | 0.85 | BACE1 (0.36) | ALDH1A1KDM4EATMTP53GAA | |
| SCHEMBL8946372 | 0.78 | MEN1 (0.49) | ALDH1A1TP53LMNAGAAMAPT | |
| SCHEMBL8946379 | 0.78 | MEN1 (0.49) | ALDH1A1TP53LMNAGAAMAPT | |
| SCHEMBL8946367 | 0.78 | MEN1 (0.49) | ALDH1A1TP53LMNAGAAMAPT | |
| SCHEMBL8946511 | 0.74 | ALDH1A1 (0.35) | ALDH1A1TP53MAPTSIGMAR1 | |
| SCHEMBL8946505 | 0.74 | ALDH1A1 (0.35) | ALDH1A1TP53MAPTSIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0409410-B1 | Indenoindole compounds | UNIV BATH (GB) | 1996-03-20 | — | — | EP | claimed |
| US-5516788-A | TREATMENT OF ATHEROSCLEROSIS; ANTIISCHEMIC, ANTICARCINOGENIC AGENTS; ANTICOAGULANTS | UNIVERSITY OF BATH (GB) | 1996-05-14 | — | — | US | disclosed |
| EP-0409410-B1 | Indenoindole compounds | UNIV BATH (GB) | 1996-03-20 | — | — | EP | disclosed |