Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 2/20 | 0.45 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.43 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.43 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.43 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.43 |
| ▸ | DRD1 | P21728 | 6/20 | 0.42 |
| ▸ | DRD5 | P21918 | 5/20 | 0.42 |
| ▸ | DRD2 | P14416 | 4/20 | 0.42 |
| ▸ | DRD3 | P35462 | 4/20 | 0.42 |
| ▸ | DRD4 | P21917 | 3/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8946972 | 1.00 | HTR2A (0.45) | HTR2AOPRM1SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL8946988 | 1.00 | HTR2A (0.45) | HTR2AOPRM1SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL8946437 | 0.82 | SLC6A2 (0.40) | HTR2AOPRM1SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL8946433 | 0.82 | SLC6A2 (0.40) | HTR2AOPRM1SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL8946442 | 0.82 | SLC6A2 (0.40) | HTR2AOPRM1SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL10380873 | 0.81 | HPGD (0.55) | HTR2AOPRM1SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL24793785 | 0.81 | HTR2A (0.43) | HTR2AOPRM1SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL8946743 | 0.81 | ADRA2A (0.41) | HTR2AOPRM1SLC6A2SLC6A4 | |
| SCHEMBL8946747 | 0.81 | ADRA2A (0.41) | HTR2AOPRM1SLC6A2SLC6A4 | |
| SCHEMBL8946720 | 0.81 | ADRA2A (0.41) | HTR2AOPRM1SLC6A2SLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5516788-A | TREATMENT OF ATHEROSCLEROSIS; ANTIISCHEMIC, ANTICARCINOGENIC AGENTS; ANTICOAGULANTS | UNIVERSITY OF BATH (GB) | 1996-05-14 | — | — | US | claimed |
| EP-0409410-B1 | Indenoindole compounds | UNIV BATH (GB) | 1996-03-20 | — | — | EP | claimed |
| US-5516788-A | TREATMENT OF ATHEROSCLEROSIS; ANTIISCHEMIC, ANTICARCINOGENIC AGENTS; ANTICOAGULANTS | UNIVERSITY OF BATH (GB) | 1996-05-14 | — | — | US | disclosed |
| EP-0409410-B1 | Indenoindole compounds | UNIV BATH (GB) | 1996-03-20 | — | — | EP | disclosed |
| EP-0409410-A1 | Indenoindole compounds | UNIVERSITY OF BATH (GB) | 1991-01-23 | — | — | EP | disclosed |
| WO-1990015799-A1 | INDENOINDOLE COMPOUNDS II | UNIVERSITY OF BATH (GB) | 1990-12-27 | — | — | WO | disclosed |