Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.62 |
| ▸ | GAA | P10253 | 2/20 | 0.62 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.49 |
| ▸ | MEN1 | O00255 | 5/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | TNFRSF1A | P19438 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.41 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.41 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.41 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.41 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.41 |
| ▸ | VCAM1 | P19320 | 1/20 | 0.41 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8947077 | 0.86 | GAA (0.59) | KDM4EGAAKMT2AMEN1SMN1; SMN2 | |
| SCHEMBL8606733 | 0.82 | KMT2A (0.49) | KDM4EGAAKMT2AMEN1SMN1; SMN2 | |
| SCHEMBL4783009 | 0.81 | ALDH1A1 (0.49) | KDM4EGAAKMT2AMEN1TSHR | |
| SCHEMBL8947318 | 0.81 | KMT2A (0.67) | KDM4EGAAKMT2AMEN1SMN1; SMN2 | |
| SCHEMBL8608296 | 0.80 | TNFRSF1A (0.41) | KDM4EGAAKMT2AMEN1HSD17B10 | |
| SCHEMBL8608298 | 0.80 | MEN1 (0.54) | KMT2AMEN1SMN1; SMN2MAPK1ALOX5 | |
| SCHEMBL5677096 | 0.76 | TNFRSF1A (0.51) | KDM4EGAATSHRTNFRSF1AALDH1A1 | |
| SCHEMBL8947267 | 0.75 | KDM4E (0.67) | KDM4EGAAKMT2AMEN1SMN1; SMN2 | |
| SCHEMBL8607619 | 0.75 | KMT2A (0.45) | KMT2AMEN1SMN1; SMN2TSHRMAPK1 | |
| SCHEMBL3637333 | 0.74 | TNFRSF1A (0.56) | TNFRSF1APKMPTGS2EPHX2NR1H4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-RE35281-E | ANTIDIABETIC AGENTS | WAKAMOTO PHARMACEUTICAL CO., LTD. (JP) | 1996-06-18 | — | — | US | disclosed |
| EP-0388967-B1 | Aldose reductase inhibitor | WAKAMOTO PHARMA CO LTD (JP) | 1995-06-28 | — | — | EP | disclosed |
| US-5055481-A | Alleviate diabetic complications | WAKAMOTO PHARMACEUTICAL CO., LTD. (JP) | 1991-10-08 | — | — | US | disclosed |
| EP-0388967-A1 | Aldose reductase inhibitor | Wakamoto Pharmaceutical Co., Ltd. (JP) | 1990-09-26 | — | — | EP | disclosed |