Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 1/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.51 |
| ▸ | HPGD | P15428 | 1/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.50 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | ERCC5 | P28715 | 1/20 | 0.46 |
| ▸ | FEN1 | P39748 | 1/20 | 0.46 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 3/20 | 0.45 |
| ▸ | NPC1 | O15118 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | RAB9A | P51151 | 2/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.43 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8947317 | 0.93 | ALDH1A1 (0.57) | HSD11B1ALDH1A1HPGDTRPV1HTT | |
| SCHEMBL8947240 | 0.89 | ALDH1A1 (0.54) | HSD11B1ALDH1A1HPGDTRPV1SMN1; SMN2 | |
| SCHEMBL5966725 | 0.87 | ALDH1A1 (0.68) | HSD11B1ALDH1A1HPGDTDP1HTT | |
| SCHEMBL8947215 | 0.87 | MGLL (0.56) | HSD11B1ALDH1A1HPGDTRPV1HTT | |
| SCHEMBL8947149 | 0.86 | ALDH1A1 (0.51) | HSD11B1ALDH1A1HPGDTRPV1HTT | |
| SCHEMBL8947311 | 0.86 | ALDH1A1 (0.57) | HSD11B1ALDH1A1HPGDTRPV1HTT | |
| SCHEMBL8947278 | 0.86 | ALDH1A1 (0.70) | HSD11B1ALDH1A1HPGDTRPV1PTGS2 | |
| SCHEMBL8947310 | 0.86 | TRPV1 (0.63) | HSD11B1ALDH1A1HPGDTRPV1HTT | |
| SCHEMBL8947125 | 0.86 | L3MBTL1 (0.48) | HSD11B1ALDH1A1HPGDTRPV1TSHR | |
| SCHEMBL5966689 | 0.86 | TRPV1 (0.59) | HSD11B1ALDH1A1HPGDTRPV1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-RE35281-E | ANTIDIABETIC AGENTS | WAKAMOTO PHARMACEUTICAL CO., LTD. (JP) | 1996-06-18 | — | — | US | disclosed |
| EP-0388967-B1 | Aldose reductase inhibitor | WAKAMOTO PHARMA CO LTD (JP) | 1995-06-28 | — | — | EP | disclosed |
| US-5055481-A | Alleviate diabetic complications | WAKAMOTO PHARMACEUTICAL CO., LTD. (JP) | 1991-10-08 | — | — | US | disclosed |
| EP-0388967-A1 | Aldose reductase inhibitor | Wakamoto Pharmaceutical Co., Ltd. (JP) | 1990-09-26 | — | — | EP | disclosed |