Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLK1 | P53350 | 1/20 | 0.62 |
| ▸ | CA2 | P00918 | 1/20 | 0.58 |
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.51 |
| ▸ | MEN1 | O00255 | 2/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.51 |
| ▸ | TSHR | P16473 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.51 |
| ▸ | RARB | P10826 | 1/20 | 0.50 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.50 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.49 |
| ▸ | MMP1 | P03956 | 1/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.49 |
| ▸ | THRA | P10827 | 1/20 | 0.49 |
| ▸ | THRB | P10828 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15174084 | 0.94 | PLK1 (0.55) | PLK1CA2TRPV1MEN1KMT2A | |
| SCHEMBL8947232 | 0.94 | PLK1 (0.55) | PLK1CA2TRPV1MEN1KMT2A | |
| SCHEMBL8947346 | 0.84 | ALDH1A1 (0.58) | PLK1KDM4EMEN1KMT2ATSHR | |
| SCHEMBL8947242 | 0.83 | KMT2A (0.67) | KDM4EMEN1KMT2ATSHRSMN1; SMN2 | |
| SCHEMBL10949157 | 0.82 | PLK1 (0.72) | PLK1TRPV1KDM4EMEN1KMT2A | |
| SCHEMBL7931204 | 0.82 | PLK1 (0.55) | PLK1MEN1KMT2ANPC1RAB9A | |
| SCHEMBL8947350 | 0.82 | MMP1 (0.72) | PLK1MEN1KMT2ASMN1; SMN2HSD17B10 | |
| SCHEMBL10948379 | 0.81 | PLK1 (0.70) | PLK1TRPV1KDM4EMEN1KMT2A | |
| SCHEMBL10949132 | 0.81 | PLK1 (0.70) | PLK1TRPV1MEN1KMT2ATSHR | |
| SCHEMBL16982003 | 0.81 | KMT2A (0.50) | KDM4EMEN1KMT2ATSHRSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-RE35281-E | ANTIDIABETIC AGENTS | WAKAMOTO PHARMACEUTICAL CO., LTD. (JP) | 1996-06-18 | — | — | US | disclosed |
| EP-0388967-B1 | Aldose reductase inhibitor | WAKAMOTO PHARMA CO LTD (JP) | 1995-06-28 | — | — | EP | disclosed |
| US-5055481-A | Alleviate diabetic complications | WAKAMOTO PHARMACEUTICAL CO., LTD. (JP) | 1991-10-08 | — | — | US | disclosed |
| EP-0388967-A1 | Aldose reductase inhibitor | Wakamoto Pharmaceutical Co., Ltd. (JP) | 1990-09-26 | — | — | EP | disclosed |