Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLK1 | P53350 | 2/20 | 0.55 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.53 |
| ▸ | CA2 | P00918 | 1/20 | 0.53 |
| ▸ | THRA | P10827 | 5/20 | 0.52 |
| ▸ | THRB | P10828 | 5/20 | 0.52 |
| ▸ | RARB | P10826 | 4/20 | 0.52 |
| ▸ | MEN1 | O00255 | 2/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.52 |
| ▸ | RARA | P10276 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 1/20 | 0.52 |
| ▸ | MTOR | P42345 | 1/20 | 0.52 |
| ▸ | HAO1 | Q9UJM8 | 1/20 | 0.52 |
| ▸ | SPHK2 | Q9NRA0 | 1/20 | 0.51 |
| ▸ | SPHK1 | Q9NYA1 | 1/20 | 0.51 |
| ▸ | PLK3 | Q9H4B4 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15174084 | 1.00 | PLK1 (0.55) | PLK1TRPV1CA2THRATHRB | |
| SCHEMBL8947304 | 0.94 | PLK1 (0.62) | PLK1TRPV1CA2THRATHRB | |
| SCHEMBL9215324 | 0.85 | RARB (0.59) | PLK1TRPV1THRATHRBRARB | |
| SCHEMBL8883017 | 0.85 | THRA (0.63) | PLK1TRPV1THRATHRBRARB | |
| SCHEMBL8884118 | 0.85 | RARB (0.59) | PLK1TRPV1THRATHRBRARB | |
| SCHEMBL20810562 | 0.84 | SPHK2 (0.54) | SPHK2SPHK1 | |
| SCHEMBL28562555 | 0.83 | THRA (0.64) | PLK1TRPV1THRATHRBRARB | |
| SCHEMBL12638341 | 0.83 | SPHK1 (0.57) | PLK1TRPV1THRATHRBRARB | |
| SCHEMBL8769358 | 0.83 | PLK1 (0.57) | PLK1THRATHRBHAO1PLK3 | |
| SCHEMBL9491031 | 0.82 | L3MBTL1 (0.71) | PLK1CA2THRATHRBRARB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-RE35281-E | ANTIDIABETIC AGENTS | WAKAMOTO PHARMACEUTICAL CO., LTD. (JP) | 1996-06-18 | — | — | US | disclosed |
| EP-0388967-B1 | Aldose reductase inhibitor | WAKAMOTO PHARMA CO LTD (JP) | 1995-06-28 | — | — | EP | disclosed |
| US-5055481-A | Alleviate diabetic complications | WAKAMOTO PHARMACEUTICAL CO., LTD. (JP) | 1991-10-08 | — | — | US | disclosed |
| EP-0388967-A1 | Aldose reductase inhibitor | Wakamoto Pharmaceutical Co., Ltd. (JP) | 1990-09-26 | — | — | EP | disclosed |