Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR4 | Q13639 | 5/20 | 0.74 |
| ▸ | HTR3A | P46098 | 2/20 | 0.74 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.74 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.74 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.51 |
| ▸ | TSHR | P16473 | 1/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7340846 | 1.00 | HTR4 (0.74) | HTR4HTR3ATMEM97SIGMAR1ALDH1A1 | |
| SCHEMBL7387363 | 0.95 | HTR3A (0.68) | HTR4HTR3ATMEM97SIGMAR1 | |
| SCHEMBL7387366 | 0.95 | HTR3A (0.68) | HTR4HTR3ATMEM97SIGMAR1 | |
| SCHEMBL8947433 | 0.86 | HTR4 (0.73) | HTR4HTR3ATMEM97SIGMAR1 | |
| SCHEMBL30428794 | 0.86 | HTR4 (0.73) | HTR4HTR3ATMEM97SIGMAR1 | |
| SCHEMBL30139058 | 0.86 | HTR4 (0.73) | HTR4HTR3ATMEM97SIGMAR1 | |
| SCHEMBL3096608 | 0.86 | HTR4 (0.73) | HTR4HTR3ATMEM97SIGMAR1 | |
| Hydrochloric Acid SCHEMBL7637431 | 0.85 | HTR4 (0.72) | HTR4HTR3ATMEM97SIGMAR1 | |
| SCHEMBL1041383 | 0.85 | HTR4 (1.00) | HTR4HTR3ATMEM97SIGMAR1 | |
| Hydrochloric Acid SCHEMBL7634797 | 0.85 | HTR4 (0.72) | HTR4HTR3ATMEM97SIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5552408-A | Benzimidazoline-2-oxo-1-carboxylic acid derivatives useful as 5-ht receptor antagonists | BOEHRINGER INGELHEIM ITALIA S.P.A. (IT) | 1996-09-03 | — | — | US | claimed |
| US-5358954-A | Antiserotonine agent, antiemetic, gastrointestinal disorders | BOEHRINGER INGELHEIM ITALIA (IT) | 1994-10-25 | — | — | US | claimed |
| US-5223511-A | Benzimidazoline-2-oxo-1-carboxylic acid compounds useful as 5-HT receptor antagonists | BOEHRINGER INGELHEIM ITALIA S.P.A. (IT) | 1993-06-29 | — | — | US | claimed |
| US-5552408-A | Benzimidazoline-2-oxo-1-carboxylic acid derivatives useful as 5-ht receptor antagonists | BOEHRINGER INGELHEIM ITALIA S.P.A. (IT) | 1996-09-03 | — | — | US | disclosed |
| US-5358954-A | Antiserotonine agent, antiemetic, gastrointestinal disorders | BOEHRINGER INGELHEIM ITALIA (IT) | 1994-10-25 | — | — | US | disclosed |
| EP-0309423-B1 | New benzimidazoline-2-oxo-1-carboxylic acid derivatives useful as 5-ht receptor antagonists | BOEHRINGER INGELHEIM ITALIA (IT) | 1994-06-15 | — | — | EP | disclosed |
| US-5223511-A | Benzimidazoline-2-oxo-1-carboxylic acid compounds useful as 5-HT receptor antagonists | BOEHRINGER INGELHEIM ITALIA S.P.A. (IT) | 1993-06-29 | — | — | US | disclosed |
| EP-0309423-A2 | New benzimidazoline-2-oxo-1-carboxylic acid derivatives useful as 5-ht receptor antagonists | BOEHRINGER INGELHEIM ITALIA S.p.A. (IT) | 1989-03-29 | — | — | EP | disclosed |