Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR4 | Q13639 | 6/20 | 0.73 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.70 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.70 |
| ▸ | HTR3A | P46098 | 1/20 | 0.70 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30139058 | 1.00 | HTR4 (0.73) | HTR4TMEM97SIGMAR1HTR3A | |
| SCHEMBL3096608 | 1.00 | HTR4 (0.73) | HTR4TMEM97SIGMAR1HTR3A | |
| SCHEMBL30428794 | 1.00 | HTR4 (0.73) | HTR4TMEM97SIGMAR1HTR3A | |
| Hydrochloric Acid SCHEMBL29384867 | 0.99 | HTR4 (0.72) | HTR4TMEM97SIGMAR1HTR3A | |
| Hydrochloric Acid SCHEMBL7637431 | 0.99 | HTR4 (0.72) | HTR4TMEM97SIGMAR1HTR3A | |
| Hydrochloric Acid SCHEMBL7634797 | 0.99 | HTR4 (0.72) | HTR4TMEM97SIGMAR1HTR3A | |
| Hydrochloric Acid SCHEMBL10322633 | 0.99 | HTR4 (0.72) | HTR4TMEM97SIGMAR1HTR3A | |
| SCHEMBL13616746 | 0.87 | HTR4 (0.63) | HTR4TMEM97SIGMAR1HTR3A | |
| SCHEMBL8947426 | 0.86 | HTR4 (0.74) | HTR4TMEM97SIGMAR1HTR3A | |
| SCHEMBL7340846 | 0.86 | HTR4 (0.74) | HTR4TMEM97SIGMAR1HTR3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20250213564-A1 | COMPOSITIONS AND METHODS FOR THE TREATMENT OF ALZHEIMER'S DISEASE AND OTHER NEUROGENERATIVE DISEASE | THE RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC. | 2025-07-03 | — | — | US | disclosed |
| US-20230121608-A1 | Compositions and Methods for the Prevention of Stress-Induced Fear, Depressive-Like and Anxiety- Like Behavior | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2023-04-20 | — | — | US | disclosed |
| EP-4132496-A1 | COMPOSITIONS AND METHODS FOR THE PREVENTION OF STRESS-INDUCED FEAR, DEPRESSIVE-LIKE AND ANXIETY- LIKE BEHAVIOR | The Trustees of Columbia University in the City of New York (US) | 2023-02-15 | — | — | EP | disclosed |
| EP-3952852-A1 | PROPHYLACTIC EFFICACY OF SEROTONIN 4 RECEPTOR AGONISTS AGAINST STRESS | The Trustees of Columbia University in the City of New York (US) | 2022-02-16 | — | — | EP | disclosed |
| US-20220031684-A1 | PROPHYLACTIC EFFICACY OF SEROTONIN 4 RECEPTOR AGONISTS AGAINST STRESS | INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (FR) | 2022-02-03 | — | — | US | disclosed |
| WO-2020210393-A1 | PROPHYLACTIC EFFICACY OF SEROTONIN 4 RECEPTOR AGONISTS AGAINST STRESS | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2020-10-15 | — | — | WO | disclosed |
| US-5552408-A | Benzimidazoline-2-oxo-1-carboxylic acid derivatives useful as 5-ht receptor antagonists | BOEHRINGER INGELHEIM ITALIA S.P.A. (IT) | 1996-09-03 | — | — | US | disclosed |
| US-5358954-A | Antiserotonine agent, antiemetic, gastrointestinal disorders | BOEHRINGER INGELHEIM ITALIA (IT) | 1994-10-25 | — | — | US | disclosed |
| US-5223511-A | Benzimidazoline-2-oxo-1-carboxylic acid compounds useful as 5-HT receptor antagonists | BOEHRINGER INGELHEIM ITALIA S.P.A. (IT) | 1993-06-29 | — | — | US | disclosed |