Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B | Q13370 | 1/20 | 0.43 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.43 |
| ▸ | MKNK1 | Q9BUB5 | 4/20 | 0.38 |
| ▸ | HTR1A | P08908 | 3/20 | 0.38 |
| ▸ | HTR2C | P28335 | 3/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8947871 | 0.75 | DRD2 (0.48) | PDE3BPDE3AHTR1AHTR2C | |
| SCHEMBL11206860 | 0.74 | PDE3B (0.61) | PDE3BPDE3AMKNK1HTR1AHTR2C | |
| SCHEMBL11336169 | 0.70 | PDE3B (0.56) | PDE3BPDE3AMKNK1HTR1AHTR2C | |
| SCHEMBL7762986 | 0.70 | HTR1A (0.45) | PDE3BPDE3AHTR1AHTR2C | |
| SCHEMBL15534441 | 0.69 | PDE3B (0.54) | PDE3BPDE3AMKNK1HTR1AHTR2C | |
| SCHEMBL8948133 | 0.69 | HTR1A (0.53) | HTR1AHTR2C | |
| SCHEMBL10986865 | 0.69 | DRD2 (0.47) | HTR1A | |
| Hydrochloric Acid SCHEMBL10867793 | 0.68 | APEX1 (0.48) | HTR1A | |
| Hydrochloric Acid SCHEMBL10754007 | 0.67 | HTR1A (0.38) | HTR1AHTR2C | |
| SCHEMBL11347101 | 0.66 | PDE3B (0.54) | PDE3BPDE3AMKNK1HTR1AHTR2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5534517-A | (Aryl(alkyl)carbonyl)-heterocyclic compounds and their use in the treatment of anxiety and depression | ADIR ET COMPAGNIE (FR) | 1996-07-09 | — | — | US | disclosed |
| US-5387586-A | Analgesics, nervous system disorders | ADIR ET COMPAGNIE (FR) | 1995-02-07 | — | — | US | disclosed |
| EP-0613898-A1 | Aryl or arylalkyl-carbonyl heterocyclic derivatives, processes for their preparation and compositions containing them | ADIR ET COMPAGNIE (FR) | 1994-09-07 | — | — | EP | disclosed |