Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AADAT | Q8N5Z0 | 1/20 | 0.52 |
| ▸ | GFER | P55789 | 1/20 | 0.51 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | PREP | P48147 | 2/20 | 0.48 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.48 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.48 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.48 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.48 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.48 |
| ▸ | TMEM97 | Q5BJF2 | 3/20 | 0.48 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.48 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL953139 | 0.81 | AADAT (0.52) | AADATGFERPREPTMEM97SIGMAR1 | |
| SCHEMBL952907 | 0.81 | PREP (0.50) | AADATGFERPREPTMEM97SIGMAR1 | |
| SCHEMBL953138 | 0.81 | AADAT (0.52) | AADATGFERPREPTMEM97SIGMAR1 | |
| SCHEMBL952909 | 0.81 | PREP (0.50) | AADATGFERPREPTMEM97SIGMAR1 | |
| SCHEMBL3556069 | 0.77 | AADAT (0.51) | AADATGFERMEN1KMT2APREP | |
| SCHEMBL6468480 | 0.77 | AADAT (0.57) | AADATGFERPREPTMEM97SIGMAR1 | |
| SCHEMBL12234863 | 0.77 | PREP (0.51) | AADATGFERPREPTMEM97SIGMAR1 | |
| SCHEMBL955550 | 0.77 | AADAT (0.50) | AADATGFERMEN1KMT2APREP | |
| SCHEMBL955548 | 0.77 | AADAT (0.50) | AADATGFERMEN1KMT2APREP | |
| SCHEMBL8118536 | 0.76 | CHRNB2 (0.62) | EPHX2CHRNB2CHRNB4CHRNA3CHRNA7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5559242-A | FROM PYROGLUTAMIC ACID, ESTERIFICATION, REACTION WITH DIANION OF ACETONE OXIME, CYCLIZATION, REDUCTION, ALKYLATION | ABBOTT LABORATORIES (US) | 1996-09-24 | — | — | US | disclosed |
| EP-0717741-A1 | METHOD OF PREPARING ENANTIOMERICALLY-PURE 3-METHYL-5-(1-ALKYL-2(S)-PYRROLIDINYL)ISOXAZOLES | ABBOTT LABORATORIES (US) | 1996-06-26 | — | — | EP | disclosed |
| US-5516912-A | FROM PROTECTED 2-OXOPYRROLIDINE | ABBOTT LABORATORIES (US) | 1996-05-14 | — | — | US | disclosed |
| US-5508418-A | FOR MAKING CHOLINERGIC OR ANXIOLYTIC AGENTS | ABBOTT LABORATORIES (US) | 1996-04-16 | — | — | US | disclosed |
| US-5424444-A | Reacting N-alkyl-L-proline ester with salt of dianion of acetone oxime or acetonitrile or other imine anion compounds; cyclization, dehydration after reaction with Grignard reagent and hydroxylamine | ABBOTT LABORATORIES (US) | 1995-06-13 | — | — | US | disclosed |
| WO-1995007277-A1 | METHOD OF PREPARING ENANTIOMERICALLY-PURE 3-METHYL-5-(1-ALKYL-2(S)-PYRROLIDINYL)ISOXAZOLES | ABBOTT LABORATORIES (US) | 1995-03-16 | — | — | WO | disclosed |