SCHEMBL8948583

SCHEMBL8948583

O=C(Cl)c1ccc2cc(-c3ccc(C(=O)O)c(-c4ccc5cc(C(=O)Cl)ccc5c4)c3C(=O)O)ccc2c1

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP1A2 P05177 1/20 0.46
CYP2D6 P10635 1/20 0.46
CYP2C9 P11712 1/20 0.46
TSHR P16473 1/20 0.46
CYP2C19 P33261 1/20 0.46
SOS1 Q07889 1/20 0.46
HIF1A Q16665 1/20 0.46
FABP3 P05413 1/20 0.36
FABP4 P15090 1/20 0.36
FABP5 Q01469 1/20 0.36
SMN1; SMN2 Q16637 2/20 0.35
ACMSD Q8TDX5 1/20 0.35
RARB P10826 5/20 0.35
RARG P13631 5/20 0.35
RARA P10276 4/20 0.34
HSD17B10 Q99714 3/20 0.33
ALOX15 P16050 2/20 0.33
KDM4E B2RXH2 1/20 0.33
MEN1 O00255 1/20 0.33
ALDH1A1 P00352 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8948814 0.90 CYP1A2 (0.49) CYP1A2CYP2D6CYP2C9TSHRCYP2C19
SCHEMBL8948670 0.83 FOLH1 (0.38) CYP1A2CYP2D6CYP2C9TSHRCYP2C19
SCHEMBL9489942 0.81 FABP3 (0.48) CYP1A2CYP2D6CYP2C9TSHRCYP2C19
SCHEMBL8948605 0.75 FOLH1 (0.47) CYP2C9TSHRSMN1; SMN2HSD17B10TP53
SCHEMBL10906083 0.73 CA1 (0.44) HIF1AFABP4ACMSDHSD17B10KDM4E
SCHEMBL10783650 0.73 FOLH1 (0.54) KDM4EFOLH1RXRARXRBPTPN11
SCHEMBL23630423 0.72 PTPN1 (0.47) CYP1A2TSHRCYP2C19SOS1SMN1; SMN2
SCHEMBL9443383 0.71 RARB (0.49) CYP1A2CYP2D6CYP2C9TSHRCYP2C19
SCHEMBL10908856 0.70 MCL1 (0.49) HIF1ASMN1; SMN2ACMSDHSD17B10KDM4E
SCHEMBL8948602 0.70 PTPN1 (0.57) CYP1A2CYP2D6CYP2C9TSHRCYP2C19

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5525699-A Copolymers having a controlled sequence structure HOECHST CELANESE CORP. (US) 1996-06-11 US disclosed
EP-0569930-A2 Copolymers having a controlled sequence structure HOECHST CELANESE CORPORATION (US) 1993-11-18 EP disclosed