SCHEMBL8948826

SCHEMBL8948826

Cc1cc(C)c(-c2c(C)cc(C)c3c2C(=O)c2ccccc2C3)c2c1Cc1ccccc1C2=O

nearest known ligand 0.50

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAOA P21397 2/20 0.50
CES1 P23141 2/20 0.47
BCHE P06276 1/20 0.47
ALDH1A1 P00352 7/20 0.45
CYP1A2 P05177 2/20 0.45
CYP2C19 P33261 1/20 0.45
KMT2A Q03164 6/20 0.42
MEN1 O00255 5/20 0.42
KDM4E B2RXH2 4/20 0.42
SMN1; SMN2 Q16637 3/20 0.42
MAPT P10636 3/20 0.42
NPC1 O15118 1/20 0.42
RAB9A P51151 1/20 0.42
ELANE P08246 1/20 0.40
MAP3K9 P80192 1/20 0.40
MAP3K11 Q16584 1/20 0.40
ACHE P22303 1/20 0.40
TTR P02766 1/20 0.40
MIF P14174 1/20 0.39
MAOB P27338 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8948832 0.88 MAOA (0.39) MAOACES1BCHEALDH1A1CYP1A2
SCHEMBL6903907 0.83 MAOA (0.53) MAOACES1BCHEALDH1A1CYP1A2
SCHEMBL8163015 0.77 MAP3K9 (0.41) MAOACES1BCHEALDH1A1CYP1A2
SCHEMBL6906767 0.77 MAOA (0.55) MAOACES1BCHEALDH1A1CYP1A2
SCHEMBL6900208 0.77 MAOA (0.55) MAOACES1BCHEALDH1A1CYP1A2
SCHEMBL31589075 0.76 MAOA (0.53) MAOACES1BCHEALDH1A1CYP1A2
SCHEMBL15960870 0.76 MAOA (0.53) MAOACES1BCHEALDH1A1CYP1A2
SCHEMBL30177232 0.74 MAOA (0.61) MAOACES1BCHEALDH1A1CYP1A2
SCHEMBL10694265 0.74 MAOA (0.61) MAOACES1BCHEALDH1A1CYP1A2
SCHEMBL4652610 0.74 MAOA (0.61) MAOACES1BCHEALDH1A1CYP1A2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2686045-A2 DETECTION OF MECHANICAL STRESS ON COATED ARTICLES SiO2 Medical Products, Inc. (US) 2014-01-22 EP claimed
WO-2012125736-A2 DETECTION OF MECHANICAL STRESS ON COATED ARTICLES SIO2 MEDICAL PRODUCTS, INC. (US) 2012-09-20 WO claimed
US-20140069202-A1 DETECTION OF MECHANICAL STRESS ON COATED ARTICLES SIO2 MEDICAL PRODUCTS, LLC 2014-03-13 US disclosed
EP-2686045-A2 DETECTION OF MECHANICAL STRESS ON COATED ARTICLES SiO2 Medical Products, Inc. (US) 2014-01-22 EP disclosed
WO-2012125736-A2 DETECTION OF MECHANICAL STRESS ON COATED ARTICLES SIO2 MEDICAL PRODUCTS, INC. (US) 2012-09-20 WO disclosed
US-5501945-A Method of using multichromic polymers in packaging THE UNIVERSITY OF AKRON (US) 1996-03-26 US disclosed