Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 4/20 | 0.38 |
| ▸ | ITGB3 | P05106 | 2/20 | 0.36 |
| ▸ | ITGA2B | P08514 | 2/20 | 0.36 |
| ▸ | EGLN1 | Q9GZT9 | 2/20 | 0.35 |
| ▸ | FASN | P49327 | 2/20 | 0.35 |
| ▸ | SYK | P43405 | 2/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | TMPRSS15 | P98073 | 1/20 | 0.34 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.34 |
| ▸ | DPP4 | P27487 | 1/20 | 0.33 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.33 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.33 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8948981 | 1.00 | GPR119 (0.38) | GPR119ITGB3ITGA2BEGLN1FASN | |
| SCHEMBL8949356 | 0.89 | TMPRSS15 (0.43) | EGLN1FASNSYKPOLBHPGD | |
| SCHEMBL8949363 | 0.89 | TMPRSS15 (0.43) | EGLN1FASNSYKPOLBHPGD | |
| SCHEMBL8949414 | 0.85 | ITGB3 (0.39) | ITGB3ITGA2BEGLN1FASNSYK | |
| SCHEMBL8949416 | 0.85 | ITGB3 (0.39) | ITGB3ITGA2BEGLN1FASNSYK | |
| SCHEMBL8949156 | 0.84 | POLB (0.40) | GPR119EGLN1SYKPOLBHPGD | |
| SCHEMBL8949150 | 0.84 | POLB (0.40) | GPR119EGLN1SYKPOLBHPGD | |
| SCHEMBL8949176 | 0.83 | POLB (0.36) | ITGB3ITGA2BEGLN1FASNSYK | |
| SCHEMBL8949178 | 0.83 | POLB (0.36) | ITGB3ITGA2BEGLN1FASNSYK | |
| SCHEMBL8948982 | 0.79 | EGLN1 (0.38) | GPR119EGLN1FASNSYKPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5563268-A | FOR PREVENTING CELL AGGLOMERATION, TREATING THROMBOSIS, ARTERIOSCLEROSIS, BRAIN, LUNG OR CARDIOVASCULAR DISORDERS | DR. KARL THOMAE GMBH (DE) | 1996-10-08 | — | — | US | disclosed |
| US-5418233-A | FOR INHIBITING CELL AGGREGATION | KARL THOMAE GMBH (DE) | 1995-05-23 | — | — | US | disclosed |
| EP-0537696-A1 | Heterobiaryl derivatives, medicines containing those compounds and process for their preparation | Dr. Karl Thomae GmbH (DE) | 1993-04-21 | — | — | EP | disclosed |