Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PHGDH | O43175 | 1/20 | 0.43 |
| ▸ | HDAC3 | O15379 | 5/20 | 0.43 |
| ▸ | HDAC4 | P56524 | 5/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 5/20 | 0.43 |
| ▸ | HDAC2 | Q92769 | 5/20 | 0.43 |
| ▸ | HDAC8 | Q9BY41 | 5/20 | 0.43 |
| ▸ | HDAC6 | Q9UBN7 | 5/20 | 0.43 |
| ▸ | HDAC7 | Q8WUI4 | 4/20 | 0.43 |
| ▸ | HDAC10 | Q969S8 | 4/20 | 0.43 |
| ▸ | HDAC11 | Q96DB2 | 4/20 | 0.43 |
| ▸ | HDAC9 | Q9UKV0 | 4/20 | 0.43 |
| ▸ | HDAC5 | Q9UQL6 | 4/20 | 0.43 |
| ▸ | EGLN1 | Q9GZT9 | 7/20 | 0.41 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.40 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.40 |
| ▸ | EGLN2 | Q96KS0 | 2/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | KDM1A | O60341 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9571680 | 0.87 | EGLN1 (0.42) | PHGDHHDAC3HDAC4HDAC1HDAC2 | |
| SCHEMBL8949033 | 0.83 | ITGB3 (0.51) | HDAC3HDAC4HDAC1HDAC2HDAC8 | |
| SCHEMBL8949066 | 0.82 | ALDH1A1 (0.46) | PHGDHEGLN1CHRM4MAPK1KDM4E | |
| SCHEMBL8949063 | 0.80 | ITGB3 (0.47) | HDAC3HDAC4HDAC1HDAC2HDAC8 | |
| SCHEMBL5230660 | 0.80 | HDAC3 (0.44) | HDAC3HDAC4HDAC1HDAC2HDAC8 | |
| SCHEMBL7275259 | 0.79 | PHGDH (0.48) | PHGDHEGLN2KDM4EALDH1A1GAA | |
| Hydrochloric Acid SCHEMBL8949308 | 0.78 | KDM1A (0.40) | PHGDHEGLN1AOC3MAPK1KDM1A | |
| Hydrochloric Acid SCHEMBL9264740 | 0.78 | ALDH1A1 (0.42) | PHGDHEGLN1CHRM4MAPK1KDM1A | |
| SCHEMBL8949239 | 0.76 | ITGB3 (0.45) | — | |
| SCHEMBL8949269 | 0.75 | EGLN1 (0.47) | PHGDHEGLN1KDM1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5563268-A | FOR PREVENTING CELL AGGLOMERATION, TREATING THROMBOSIS, ARTERIOSCLEROSIS, BRAIN, LUNG OR CARDIOVASCULAR DISORDERS | DR. KARL THOMAE GMBH (DE) | 1996-10-08 | — | — | US | disclosed |
| US-5418233-A | FOR INHIBITING CELL AGGREGATION | KARL THOMAE GMBH (DE) | 1995-05-23 | — | — | US | disclosed |
| EP-0537696-A1 | Heterobiaryl derivatives, medicines containing those compounds and process for their preparation | Dr. Karl Thomae GmbH (DE) | 1993-04-21 | — | — | EP | disclosed |