SCHEMBL8949578

SCHEMBL8949578

CC1=C(OC(=O)O)C(c2cccc([N+](=O)[O-])c2Cl)C(OC(=O)OC(C)C)=C(C)N1

nearest known ligand 0.42

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CACNA1C Q13936 6/20 0.42
CACNA1D Q01668 6/20 0.42
CACNA1F O60840 5/20 0.42
CACNA1S Q13698 5/20 0.42
KMT2A Q03164 5/20 0.42
LMNA P02545 4/20 0.42
CYP1A2 P05177 4/20 0.42
MAPT P10636 4/20 0.42
ADORA3 P0DMS8 3/20 0.42
CYP3A4 P08684 3/20 0.42
CYP2C9 P11712 3/20 0.42
CYP2C19 P33261 3/20 0.42
ABCC4 O15439 2/20 0.42
ABCB11 O95342 2/20 0.42
ADORA2A P29274 2/20 0.42
ADORA1 P30542 2/20 0.42
OPRM1 P35372 2/20 0.42
SCN1A P35498 2/20 0.42
HTR2B P41595 2/20 0.42
KCNH2 Q12809 2/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8949402 0.86 CACNA1D (0.41) CACNA1CCACNA1DCACNA1FCACNA1SKMT2A
SCHEMBL11369478 0.83 CYP1A2 (0.60) CACNA1CCACNA1DCACNA1FCACNA1SKMT2A
SCHEMBL11360822 0.80 ADORA3 (0.62) CACNA1CCACNA1DCACNA1FCACNA1SKMT2A
SCHEMBL9845937 0.80 CACNA1C (0.63) CACNA1CCACNA1DCACNA1FCACNA1SKMT2A
SCHEMBL10913589 0.78 CACNA1D (0.51) CACNA1CCACNA1DCACNA1FCACNA1SKMT2A
SCHEMBL10376262 0.78 CACNA1D (0.63) CACNA1CCACNA1DCACNA1FCACNA1SKMT2A
SCHEMBL10374091 0.78 MEN1 (0.57) CACNA1CCACNA1DCACNA1FCACNA1SKMT2A
SCHEMBL10377263 0.77 CACNA1D (0.55) CACNA1CCACNA1DCACNA1FCACNA1SKMT2A
SCHEMBL11357267 0.77 CACNA1D (0.47) CACNA1CCACNA1DCACNA1FCACNA1SKMT2A
SCHEMBL11119301 0.77 LMNA (0.49) CACNA1CCACNA1DCACNA1FCACNA1SKMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0595164-B1 4-heterocyclephenyl substituted dihydropyridines BAYER AG (DE) 1996-12-27 EP disclosed
EP-0595164-A1 4-heterocyclephenyl substituted dihydropyridines BAYER AG (DE) 1994-05-04 EP disclosed