SCHEMBL8949402

SCHEMBL8949402

CC1=C(OC(=O)OCCC#N)C(c2cccc([N+](=O)[O-])c2Cl)C(OC(=O)OC(C)C)=C(C)N1

nearest known ligand 0.42

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CACNA1D Q01668 7/20 0.41
CACNA1C Q13936 6/20 0.41
CACNA1F O60840 5/20 0.41
CACNA1S Q13698 5/20 0.41
CYP1A2 P05177 5/20 0.40
LMNA P02545 4/20 0.40
ADORA3 P0DMS8 4/20 0.40
SCN5A Q14524 3/20 0.40
ABCC4 O15439 2/20 0.40
ABCB11 O95342 2/20 0.40
ADORA2A P29274 2/20 0.40
ADORA1 P30542 2/20 0.40
OPRM1 P35372 2/20 0.40
SCN1A P35498 2/20 0.40
HTR2B P41595 2/20 0.40
KCNH2 Q12809 2/20 0.40
SCN2A Q99250 2/20 0.40
SCN3A Q9NY46 2/20 0.40
NR1I2 O75469 2/20 0.40
NR3C1 P04150 2/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8949578 0.86 CACNA1C (0.42) CACNA1DCACNA1CCACNA1FCACNA1SCYP1A2
SCHEMBL9284454 0.84 CYP1A2 (0.53) CACNA1DCACNA1CCACNA1FCACNA1SCYP1A2
SCHEMBL11279053 0.83 CACNA1D (0.53) CACNA1DCACNA1CCACNA1FCACNA1SCYP1A2
SCHEMBL11498482 0.82 CACNA1D (0.57) CACNA1DCACNA1CCACNA1FCACNA1SCYP1A2
SCHEMBL11498577 0.82 CACNA1D (0.49) CACNA1DCACNA1CCACNA1FCACNA1SCYP1A2
SCHEMBL10913858 0.81 MEN1 (0.57) CACNA1DCACNA1CCACNA1FCACNA1SCYP1A2
SCHEMBL11276232 0.80 TSHR (0.39) CACNA1DCACNA1CCACNA1FCACNA1SCYP1A2
SCHEMBL10913589 0.80 CACNA1D (0.51) CACNA1DCACNA1CCACNA1FCACNA1SCYP1A2
SCHEMBL11280776 0.79 CACNA1B (0.44) CACNA1DCACNA1CCACNA1FCACNA1SCYP1A2
SCHEMBL11119301 0.79 LMNA (0.49) CACNA1DCACNA1CCACNA1FCACNA1SCYP1A2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0595164-B1 4-heterocyclephenyl substituted dihydropyridines BAYER AG (DE) 1996-12-27 EP disclosed
EP-0595164-A1 4-heterocyclephenyl substituted dihydropyridines BAYER AG (DE) 1994-05-04 EP disclosed