Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TTR | P02766 | 9/20 | 0.70 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.64 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.64 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.64 |
| ▸ | MEN1 | O00255 | 1/20 | 0.64 |
| ▸ | TP53 | P04637 | 1/20 | 0.64 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.64 |
| ▸ | HPGD | P15428 | 1/20 | 0.64 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.64 |
| ▸ | PTGER3 | P43115 | 1/20 | 0.64 |
| ▸ | PTGER2 | P43116 | 1/20 | 0.64 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.64 |
| ▸ | PTGDR | Q13258 | 1/20 | 0.64 |
| ▸ | MAOA | P21397 | 3/20 | 0.62 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.55 |
| ▸ | AKR1B1 | P15121 | 2/20 | 0.54 |
| ▸ | NPC1 | O15118 | 1/20 | 0.52 |
| ▸ | RAB9A | P51151 | 1/20 | 0.52 |
| ▸ | LMNA | P02545 | 2/20 | 0.51 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10453744 | 0.94 | TTR (0.72) | TTRKDM4EALDH1A1HSD17B10MEN1 | |
| SCHEMBL10452893 | 0.93 | TTR (0.70) | TTRKDM4EALDH1A1HSD17B10MEN1 | |
| SCHEMBL10452894 | 0.93 | TTR (0.70) | TTRKDM4EALDH1A1HSD17B10MEN1 | |
| SCHEMBL21313809 | 0.92 | TTR (0.71) | TTRKDM4EALDH1A1HSD17B10MEN1 | |
| SCHEMBL11322640 | 0.91 | TTR (0.80) | TTRKDM4EALDH1A1HSD17B10MEN1 | |
| SCHEMBL68189 | 0.87 | TTR (0.83) | TTRKDM4EALDH1A1HSD17B10MEN1 | |
| SCHEMBL31423805 | 0.85 | MAOA (0.77) | KDM4EALDH1A1HSD17B10MEN1TP53 | |
| SCHEMBL7337235 | 0.85 | MAOA (0.77) | KDM4EALDH1A1HSD17B10MEN1TP53 | |
| Hydrochloric Acid SCHEMBL11749391 | 0.85 | TTR (0.81) | TTRKDM4EALDH1A1HSD17B10MEN1 | |
| SCHEMBL11866781 | 0.84 | TTR (0.68) | TTRKDM4EALDH1A1HSD17B10MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5552441-A | ANTIALLERGENS, ANTIINFLAMMATORY AGENTS AND RESPIRATORY SYSTEM DISORDERS | ELI LILLY AND COMPANY (US) | 1996-09-03 | — | — | US | disclosed |
| EP-0442748-B1 | Improvements in and relating to leukotriene antagonists | LILLY CO ELI (US) | 1995-01-11 | — | — | EP | disclosed |
| US-5324743-A | Leukotriene B4 antagonists | ELI LILLY AND COMPANY (US) | 1994-06-28 | — | — | US | disclosed |
| EP-0442748-A1 | Improvements in and relating to leukotriene antagonists | ELI LILLY AND COMPANY (US) | 1991-08-21 | — | — | EP | disclosed |
| US-4996230-A | Antiallergens, antiinflammatory agent | ELI LILLY AND COMPANY (US) | 1991-02-26 | — | — | US | disclosed |
| US-3949084-A | Novel substituted xanthone carboxylic acid compounds | SYNTEX (U.S.A.) INC. (US) | 1976-04-06 | — | — | US | disclosed |