Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TTR | P02766 | 7/20 | 0.71 |
| ▸ | MAOA | P21397 | 3/20 | 0.63 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.57 |
| ▸ | MEN1 | O00255 | 2/20 | 0.57 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.57 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.57 |
| ▸ | TP53 | P04637 | 1/20 | 0.57 |
| ▸ | HPGD | P15428 | 1/20 | 0.57 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.57 |
| ▸ | PTGER3 | P43115 | 1/20 | 0.57 |
| ▸ | PTGER2 | P43116 | 1/20 | 0.57 |
| ▸ | PTGDR | Q13258 | 1/20 | 0.57 |
| ▸ | ESR2 | Q92731 | 2/20 | 0.56 |
| ▸ | ESR1 | P03372 | 1/20 | 0.56 |
| ▸ | MGAM | O43451 | 2/20 | 0.54 |
| ▸ | FASN | P49327 | 1/20 | 0.54 |
| ▸ | NPC1 | O15118 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10453744 | 0.92 | TTR (0.72) | TTRMAOAAKR1B1KDM4EMEN1 | |
| SCHEMBL8949782 | 0.92 | TTR (0.70) | TTRMAOAAKR1B1KDM4EMEN1 | |
| SCHEMBL68189 | 0.91 | TTR (0.83) | TTRMAOAAKR1B1KDM4EMEN1 | |
| SCHEMBL10452893 | 0.91 | TTR (0.70) | TTRMAOAAKR1B1KDM4EMEN1 | |
| SCHEMBL10452894 | 0.91 | TTR (0.70) | TTRMAOAAKR1B1KDM4EMEN1 | |
| Hydrochloric Acid SCHEMBL11749391 | 0.90 | TTR (0.81) | TTRMAOAAKR1B1KDM4EMEN1 | |
| Euxanthone SCHEMBL2161295 | 0.86 | MAOA (0.81) | MAOAKDM4EMEN1CYP2C9KMT2A | |
| SCHEMBL11322640 | 0.85 | TTR (0.80) | TTRMAOAAKR1B1KDM4EMEN1 | |
| SCHEMBL1787556 | 0.83 | TTR (1.00) | TTRMAOAAKR1B1KDM4EMEN1 | |
| SCHEMBL11883817 | 0.83 | NPC1 (0.74) | TTRAKR1B1KDM4EMEN1CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2908843-B1 | TREATING CANCER | AGENCY SCIENCE TECH & RES (SG) | 2019-09-04 | — | — | EP | claimed |