Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GCGR | P47871 | 14/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | DHODH | Q02127 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8949830 | 0.85 | GCGR (0.45) | GCGR | |
| SCHEMBL8949704 | 0.84 | NPC1 (0.43) | GCGRKDM4EMEN1NPC1MAPT | |
| SCHEMBL9744007 | 0.81 | SCN9A (0.35) | GCGR | |
| SCHEMBL28320987 | 0.75 | GCGR (0.51) | GCGR | |
| SCHEMBL2663566 | 0.72 | GCGR (0.58) | GCGR | |
| SCHEMBL8880943 | 0.70 | GCGR (0.45) | GCGRDHODH | |
| SCHEMBL8201704 | 0.69 | ADORA2A (0.43) | GCGRKDM4EMEN1NPC1MAPT | |
| SCHEMBL8949766 | 0.69 | GCGR (0.40) | GCGRKDM4EMAPT | |
| SCHEMBL10511491 | 0.69 | NPC1 (0.43) | GCGRKDM4EMEN1NPC1MAPT | |
| SCHEMBL27506734 | 0.68 | GCGR (0.41) | GCGR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5502057-A | Polysubstituted pyridines useful for treating lipoproteinanaemia and arteriosclerosis | BAYER AKTIENGESELLSCHAFT (DE) | 1996-03-26 | — | — | US | disclosed |
| US-5470982-A | Disubstituted pyridines | BAYER AKTIENGESELLSCHAFT (DE) | 1995-11-28 | — | — | US | disclosed |
| US-5173495-A | 7-[(2,6-dialkyl-4-furyl or thienyl-pyridyl)]-3,5-di-(dihydroxy-6-enoates) useful for treating circulatory diseases | BAYER AKTIENGESELLSCHAFT (DE) | 1992-12-22 | — | — | US | disclosed |
| US-4968689-A | Certain 2,6-diisopropyl-4-(4-fluoro-phenyl)-3,5-bis-dimethyl-3',5'-dihydroxy-hept-6-enoate-pyridine derivatives useful for treating lipoproteinaemia and arteriosclerosis | BAYER AKTIENGESELLSCHAFT (DE) | 1990-11-06 | — | — | US | disclosed |
| CN-1034716-A | Disubstituted pyridines and preparation method thereof | BAYER AG (DE) | 1989-08-16 | — | — | CN | disclosed |