Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 4/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.36 |
| ▸ | POLB | P06746 | 3/20 | 0.36 |
| ▸ | MAPT | P10636 | 6/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.35 |
| ▸ | GAA | P10253 | 3/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.35 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.35 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | NPC1 | O15118 | 2/20 | 0.34 |
| ▸ | RAB9A | P51151 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9057095 | 0.73 | TSHR (0.38) | TSHRHSD17B10POLBMAPTKDM4E | |
| SCHEMBL10971176 | 0.73 | HSD11B1 (0.62) | HSD11B1TSHRHSD17B10POLBMAPT | |
| SCHEMBL11481782 | 0.66 | PTGS1 (0.44) | HSD11B1TSHRHSD17B10MAPTKDM4E | |
| SCHEMBL8950426 | 0.66 | TSHR (0.39) | TSHRHSD17B10POLBMAPTKDM4E | |
| SCHEMBL8950132 | 0.65 | MAPT (0.39) | TSHRHSD17B10POLBMAPTKDM4E | |
| SCHEMBL8950389 | 0.65 | PTGER4 (0.34) | HSD11B1TSHRHSD17B10POLBMAPT | |
| SCHEMBL162212 | 0.62 | TSHR (0.55) | TSHRHSD17B10POLBMAPTKDM4E | |
| SCHEMBL2753992 | 0.62 | PTGS1 (0.51) | HSD11B1POLBMAPTKDM4EGAA | |
| SCHEMBL30822800 | 0.61 | HSD11B1 (1.00) | HSD11B1KDM4ECYP2C9CYP1A2CYP3A4 | |
| SCHEMBL225275 | 0.61 | ALDH1A1 (0.54) | TSHRHSD17B10MAPTKDM4EGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5538966-A | ENZYME INHIBITORS FOR TREATMENT OF GLAUCOMA | ALCON LABORATORIES, INC. (US) | 1996-07-23 | — | — | US | disclosed |