Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 5/20 | 0.39 |
| ▸ | POLB | P06746 | 4/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 7/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.34 |
| ▸ | ATM | Q13315 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 2/20 | 0.33 |
| ▸ | RAB9A | P51151 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | PKM | P14618 | 1/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8950389 | 0.76 | PTGER4 (0.34) | TSHRPOLBHSD17B10KDM4EMAPT | |
| SCHEMBL9058353 | 0.75 | TSHR (0.40) | TSHRPOLBHSD17B10KDM4EMAPT | |
| SCHEMBL8950417 | 0.74 | ALDH1A1 (0.44) | TSHRHSD17B10KDM4EMAPTALDH1A1 | |
| SCHEMBL8950076 | 0.74 | FEN1 (0.46) | HSD17B10KDM4EMAPTALDH1A1MAPK1 | |
| SCHEMBL8950132 | 0.70 | MAPT (0.39) | TSHRPOLBHSD17B10KDM4EMAPT | |
| SCHEMBL8950215 | 0.66 | HSD11B1 (0.44) | TSHRPOLBHSD17B10KDM4EMAPT | |
| SCHEMBL9057057 | 0.64 | MAPT (0.36) | TSHRPOLBHSD17B10KDM4EMAPT | |
| SCHEMBL9058117 | 0.62 | FEN1 (0.47) | POLBHSD17B10KDM4EMAPTALDH1A1 | |
| SCHEMBL25060076 | 0.61 | MAPT (0.42) | TSHRPOLBHSD17B10KDM4EMAPT | |
| SCHEMBL162212 | 0.60 | TSHR (0.55) | TSHRPOLBHSD17B10KDM4EMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5538966-A | ENZYME INHIBITORS FOR TREATMENT OF GLAUCOMA | ALCON LABORATORIES, INC. (US) | 1996-07-23 | — | — | US | disclosed |