Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.34 |
| ▸ | POLB | P06746 | 2/20 | 0.34 |
| ▸ | TSHR | P16473 | 2/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | PKM | P14618 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.30 |
| ▸ | GAA | P10253 | 2/20 | 0.30 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.30 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.30 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.30 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8950198 | 0.87 | GAA (0.36) | ALDH1A1POLBTSHRHSD17B10SMN1; SMN2 | |
| SCHEMBL8950221 | 0.77 | HTT (0.45) | ALDH1A1TSHRSMN1; SMN2LMNAGAA | |
| SCHEMBL8862623 | 0.77 | ALDH1A1 (0.43) | ALDH1A1POLBTSHRSMN1; SMN2PKM | |
| SCHEMBL8950386 | 0.72 | GAA (0.38) | ALDH1A1POLBTSHRSMN1; SMN2PKM | |
| SCHEMBL2277778 | 0.69 | ALDH1A1 (0.41) | ALDH1A1POLBTSHRHSD17B10SMN1; SMN2 | |
| SCHEMBL8950105 | 0.67 | ALDH1A1 (0.39) | ALDH1A1POLBSMN1; SMN2LMNAKDM4E | |
| SCHEMBL10373935 | 0.66 | ALDH1A1 (0.45) | ALDH1A1POLB | |
| SCHEMBL3017019 | 0.65 | ALDH1A1 (0.41) | ALDH1A1POLB | |
| SCHEMBL7117736 | 0.62 | GAA (0.49) | ALDH1A1POLBTSHRHSD17B10SMN1; SMN2 | |
| SCHEMBL18223814 | 0.60 | PTAFR (0.35) | GAACYP1A2CYP3A4MAPTCYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1996022099-A1 | OPHTHALMIC COMPOSITIONS FOR TREATING GLAUCOMA | ALCON LABORATORIES, INC. (US) | 1996-07-25 | — | — | WO | disclosed |
| US-5538966-A | ENZYME INHIBITORS FOR TREATMENT OF GLAUCOMA | ALCON LABORATORIES, INC. (US) | 1996-07-23 | — | — | US | disclosed |
| WO-1995019981-A1 | THIENOTHIAZINE SULFONAMIDE DERIVATIVES PROCESS AND INTERMEDIATES FOR THEIR PREPARATION AND THEIR USE AS CARBONIC ANHYDRASE INHIBITORS | ALCON LABORATORIES, INC. (US) | 1995-07-27 | — | — | WO | disclosed |