SCHEMBL8950745

SCHEMBL8950745

OCc1cc(Cl)c(Br)c(Cl)c1

nearest known ligand 0.42

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
ACHE P22303 1/20 0.42
RECQL P46063 1/20 0.37
THRB P10828 1/20 0.36
RORC P51449 1/20 0.36
NPC1 O15118 1/20 0.33
HPGD P15428 1/20 0.33
RAB9A P51151 1/20 0.33
SMN1; SMN2 Q16637 1/20 0.33
KDM4E B2RXH2 1/20 0.32
CASP6 P55212 1/20 0.32
TSHR P16473 1/20 0.32
PDCD1 Q15116 1/20 0.32
CD274 Q9NZQ7 1/20 0.32
TTR P02766 1/20 0.32
IDO1 P14902 1/20 0.31
MRGPRX4 Q96LA9 1/20 0.31
CYP3A4 P08684 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1965439 0.78 HPGD (0.48) ACHERECQLTHRBNPC1HPGD
SCHEMBL522619 0.76 ACHE (0.43) ACHERECQLTHRBRORCNPC1
SCHEMBL670342 0.76 ACHE (0.43) ACHERECQLTHRBRORCNPC1
SCHEMBL737479 0.76 HSD17B10 (0.52) ACHERECQLTHRBNPC1HPGD
SCHEMBL807271 0.75 THRB (0.44) ACHERECQLTHRBRORCNPC1
SCHEMBL3519402 0.75 CA1 (0.46) ACHERECQLTSHRCYP3A4
SCHEMBL23588139 0.74 ACHE (0.42) ACHERECQLTHRBRORCNPC1
SCHEMBL11981468 0.74 ACHE (0.42) ACHERECQLTHRBRORCNPC1
SCHEMBL15794313 0.74 ACHE (0.42) ACHERECQLTHRBKDM4ECASP6
SCHEMBL13116413 0.74 ACHE (0.42) ACHERECQLTHRBRORCNPC1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 42 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-119977778-A Preparation method of carboxyamidotriazole intermediate 广东银珠医药科技有限公司 2025-05-13 CN claimed
CN-110256343-A Chloro- 4- bromo-isoquinoline derivative of 3,5- bis- and its preparation method and application 苏州芝宇生物科技有限公司 2019-09-20 CN claimed
CN-119977778-A Preparation method of carboxyamidotriazole intermediate 广东银珠医药科技有限公司 2025-05-13 CN disclosed
EP-3491922-A1 PESTICIDAL COMPOSITIONS AND PROCESSES RELATED THERETO Dow AgroSciences LLC (US) 2019-06-05 EP disclosed
EP-2934118-B1 PESTICIDAL COMPOSITIONS AND PROCESSES RELATED THERETO DOW AGROSCIENCES LLC (US) 2018-01-31 EP disclosed
EP-2934142-B1 PESTICIDAL COMPOSITIONS AND PROCESSES RELATED THERETO DOW AGROSCIENCES LLC (US) 2018-01-31 EP disclosed
US-20180009737-A1 PESTICIDAL COMPOSITIONS AND PROCESSES RELATED THERETO DOW AGROSCIENCES LLC (US) 2018-01-11 US disclosed
US-20170217876-A1 PESTICIDAL COMPOSITIONS AND PROCESSES RELATED THERETO DOW AGROSCIENCES LLC (US) 2017-08-03 US disclosed
US-9676704-B2 Pesticidal compositions and processes related thereto DOW AGROSCIENCES LLC (US) 2017-06-13 US disclosed
US-20170156320-A1 PESTICIDAL COMPOSITIONS AND PROCESSES RELATED THERETO DOW AGROSCIENCES LLC (US) 2017-06-08 US disclosed
US-20170158597-A1 PESTICIDAL COMPOSITIONS AND PROCESSES RELATED THERETO DOW AGROSCIENCES LLC (US) 2017-06-08 US disclosed
WO-2014100190-A1 PESTICIDAL COMPOSITIONS AND PROCESSES RELATED THERETO DOW AGROSCIENCES LLC (US) 2014-06-26 WO disclosed
WO-2014100170-A1 PESTICIDAL COMPOSITIONS AND PROCESSES RELATED THERETO DOW AGROSCIENCES LLC (US) 2014-06-26 WO disclosed
US-20140171313-A1 PESTICIDAL COMPOSITIONS AND PROCESSES RELATED THERETO DOW AGROSCIENCES LLC (US) 2014-06-19 US disclosed
US-20140172387-A1 PREDICTION OF MOLECULAR BIOACTIVATION GENENTECH, INC. (US) 2014-06-19 US disclosed
US-20140171315-A1 PESTICIDAL COMPOSITIONS AND PROCESSES RELATED THERETO DOW AGROSCIENCES LLC (US) 2014-06-19 US disclosed
US-20140171309-A1 PESTICIDAL COMPOSITIONS AND PROCESSES RELATED THERETO DOW AGROSCIENCES LLC (US) 2014-06-19 US disclosed
US-5502073-A INSECTICIDES OR ANTHELMINTICS THE WELLCOME FOUNDATION (GB) 1996-03-26 US disclosed
EP-0294229-B1 NOVEL HETEROCYCLIC PESTICIDAL COMPOUNDS THE WELLCOME FOUNDATION LIMITED (GB) 1992-12-02 EP disclosed
EP-0294229-A2 Novel heterocyclic pesticidal compounds THE WELLCOME FOUNDATION LIMITED (GB) 1988-12-07 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20140171315-A1 PESTICIDAL COMPOSITIONS AND PROCESSES RELATED THERETO ACHE, DDT, PTMS ACHE 1/4885RECQL 3467/4885THRB 398/4885
US-20170158597-A1 PESTICIDAL COMPOSITIONS AND PROCESSES RELATED THERETO ACHE, DDT, PTMS ACHE 1/4885RECQL 3467/4885THRB 398/4885
US-20170217876-A1 PESTICIDAL COMPOSITIONS AND PROCESSES RELATED THERETO ACHE, DDT, MLYCD ACHE 1/4885RECQL 1581/4885THRB 2419/4885
US-20180009737-A1 PESTICIDAL COMPOSITIONS AND PROCESSES RELATED THERETO ACHE, DDT, MLYCD ACHE 1/4885RECQL 1811/4885THRB 2204/4885
US-20140171309-A1 PESTICIDAL COMPOSITIONS AND PROCESSES RELATED THERETO ACHE, DDT, PTMS ACHE 1/4885RECQL 3467/4885THRB 398/4885
US-20140171313-A1 PESTICIDAL COMPOSITIONS AND PROCESSES RELATED THERETO ACHE, DDT, PTMS ACHE 1/4885RECQL 3467/4885THRB 398/4885
US-20170156320-A1 PESTICIDAL COMPOSITIONS AND PROCESSES RELATED THERETO ACHE, DDT, PTMS ACHE 1/4885RECQL 3467/4885THRB 398/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.