Sugi Predict

Sugi Predict / Compounds / SCHEMBL8950913

SCHEMBL8950913

SCHEMBL8950913

C#CC(=O)Nc1cccc(Cl)c1

nearest known ligand 0.65

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ MEN1 O00255 6/20 0.65
▸ KMT2A Q03164 6/20 0.65
▸ LMNA P02545 2/20 0.65
▸ MAPT P10636 2/20 0.65
▸ HTT P42858 2/20 0.65
▸ ALDH1A1 P00352 2/20 0.65
▸ RAB9A P51151 4/20 0.59
▸ NPC1 O15118 3/20 0.59
▸ TDP1 Q9NUW8 1/20 0.56
▸ HTR3E A5X5Y0 1/20 0.53
▸ HTR3B O95264 1/20 0.53
▸ HTR3A P46098 1/20 0.53
▸ HTR3D Q70Z44 1/20 0.53
▸ HTR3C Q8WXA8 1/20 0.53
▸ KCNJ5 P48544 1/20 0.53
▸ KCNJ3 P48549 1/20 0.53
▸ P2RX1 P51575 1/20 0.51
▸ P2RX4 Q99571 1/20 0.51
▸ P2RX7 Q99572 1/20 0.51
▸ FADS1 O60427 1/20 0.51

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8950776 0.81 MEN1 (0.62) MEN1KMT2ALMNAMAPTHTT
SCHEMBL30475557 0.80 ALDH1A1 (0.59) MEN1KMT2ALMNAMAPTHTT
SCHEMBL3265357 0.79 KMT2A (0.71) MEN1KMT2ALMNAMAPTHTT
SCHEMBL9169028 0.79 MEN1 (0.61) MEN1KMT2ALMNAMAPTHTT
SCHEMBL8950880 0.79 MEN1 (0.61) MEN1KMT2ALMNAMAPTHTT
SCHEMBL10778269 0.79 MEN1 (0.57) MEN1KMT2ALMNAMAPTHTT
SCHEMBL2682054 0.79 KMT2A (1.00) MEN1KMT2ALMNAMAPTHTT
SCHEMBL23011635 0.79 DDX3X (0.65) MEN1KMT2ALMNAMAPTALDH1A1
SCHEMBL9169501 0.79 MEN1 (0.61) MEN1KMT2ALMNARAB9ANPC1
SCHEMBL20839858 0.77 KMT2A (0.57) MEN1KMT2ALMNAMAPTALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12415811-B2 1,2,3',5'-tetrahydro-2'h-spiro[indole-3,1'-pyrrolo[3,4-C]pyrrole]-2,3'-dione compounds as therapeutic agents activating TP53 ADAMED PHARMA S.A. (PL) 2025-09-16 — — US disclosed
CN-116234546-A GPX4 inhibitors, pharmaceutical compositions thereof and their use in the treatment of GPX4 mediated diseases 嘉兴优博生物技术有限公司 2023-06-06 — — CN disclosed
CN-111566110-B 1,2,3',5' -tetrahydro-2 ' H-spiro [ indole-3, 1' -pyrrolo [3,4-C ] pyrrole ] -2,3' -dione compounds as therapeutic agents for activating TP53 阿达梅德制药公司 2023-04-25 — — CN disclosed
EP-3740492-B1 1,2,3',5'-TETRAHYDRO-2'H-SPIRO[INDOLE-3,1'-PYRROLO[3,4-C]PYRROLE]-2,3'-DIONE COMPOUNDS AS THERAPEUTIC AGENTS ACTIVATING TP53 ADAMED PHARMA S A (PL) 2022-03-02 — — EP disclosed
US-20200354372-A1 1,2,3',5'-TETRAHYDRO-2'H-SPIRO[INDOLE-3,1'-PYRROLO[3,4-C]PYRROLE]-2,3'-DIONE COMPOUNDS AS THERAPEUTIC AGENTS ACTIVATING TP53 ADAMED PHARMA, S.A. (PL) 2020-11-12 — — US disclosed
US-20200354372-A1 1,2,3',5'-TETRAHYDRO-2'H-SPIRO[INDOLE-3,1'-PYRROLO[3,4-C]PYRROLE]-2,3'-DIONE COMPOUNDS AS THERAPEUTIC AGENTS ACTIVATING TP53 ADAMED PHARMA, S.A. (PL) 2020-11-12 — — US disclosed
CN-111566110-A 1,2,3',5' -tetrahydro-2 ' H-spiro [ indole-3, 1' -pyrrolo [3,4-C ] pyrrole ] -2,3' -dione compounds as therapeutic agents for activating TP53 阿达梅德制药公司 2020-08-21 — — CN disclosed
WO-2019141549-A9 1,2,3',5'-TETRAHYDRO-2'H-SPIRO[INDOLE-3,1'-PYRROLO[3,4-C]PYRROLE]-2,3'-DIONE COMPOUNDS AS THERAPEUTIC AGENTS ACTIVATING TP53 ADAMED PHARMA S.A. (PL) 2019-10-10 — — WO disclosed
WO-2019141549-A1 1,2,3',5'-TETRAHYDRO-2'H-SPIRO[INDOLE-3,1'-PYRROLO[3,4-C]PYRROLE]-2,3'-DIONE COMPOUNDS AS THERAPEUTIC AGENTS ACTIVATING TP53 ADAMED PHARMA S.A. (PL) 2019-07-25 — — WO disclosed
EP-3511334-A1 1,2,3',5'-TETRAHYDRO-2'H-SPIRO[INDOLE-3,1'-PYRROLO[3,4-C]PYRROLE]-2,3'-DIONE COMPOUNDS AS THERAPEUTIC AGENTS ACTIVATING TP53 Adamed sp. z o.o. (PL) 2019-07-17 — — EP disclosed
EP-3511334-A1 1,2,3',5'-TETRAHYDRO-2'H-SPIRO[INDOLE-3,1'-PYRROLO[3,4-C]PYRROLE]-2,3'-DIONE COMPOUNDS AS THERAPEUTIC AGENTS ACTIVATING TP53 Adamed sp. z o.o. (PL) 2019-07-17 — — EP disclosed
US-5538998-A PEST CONTROL AGENTS TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 1996-07-23 — — US disclosed
EP-0519427-B1 N-substituted-3-iodopropiolamide, production and use thereof TAKEDA CHEMICAL INDUSTRIES LTD (JP) 1995-04-26 — — EP disclosed
EP-0649835-A1 Halopropiolamide compound, production and use thereof TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 1995-04-26 — — EP disclosed
EP-0552418-A1 N-substituted-3-iodopropiolamide, production and use thereof TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 1993-07-28 — — EP disclosed
EP-0519427-A2 N-substituted-3-iodopropiolamide, production and use thereof TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 1992-12-23 — — EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12415811-B2 1,2,3',5'-tetrahydro-2'h-spiro[indole-3,1'-pyrrolo[3,4-C]pyrrole]-2,3'-dione compounds as therapeutic agents activating TP53 TP53, IDO1, TP53BP1 MEN1 3555/4885KMT2A 3094/4885LMNA 3114/4885
US-20200354372-A1 1,2,3',5'-TETRAHYDRO-2'H-SPIRO[INDOLE-3,1'-PYRROLO[3,4-C]PYRROLE]-2,3'-DIONE COMPOUNDS AS THERAPEUTIC AGENTS ACTIVATING TP53 TP53, IDO1, TP53BP1 MEN1 3555/4885KMT2A 3094/4885LMNA 3114/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.