Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HMGCR | P04035 | 6/20 | 0.43 |
| ▸ | GCGR | P47871 | 5/20 | 0.35 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8878236 | 1.00 | HMGCR (0.43) | HMGCRGCGRTLR8 | |
| SCHEMBL8877862 | 0.78 | HMGCR (0.44) | HMGCR | |
| SCHEMBL8875477 | 0.76 | HMGCR (0.42) | HMGCRGCGR | |
| SCHEMBL9562884 | 0.75 | HMGCR (0.54) | HMGCRGCGR | |
| SCHEMBL8953159 | 0.73 | — | — | |
| SCHEMBL8953141 | 0.73 | — | — | |
| SCHEMBL8953165 | 0.73 | — | — | |
| SCHEMBL8877555 | 0.72 | HMGCR (0.48) | HMGCRGCGR | |
| SCHEMBL8953015 | 0.71 | HMGCR (0.40) | HMGCR | |
| SCHEMBL8953011 | 0.71 | HMGCR (0.40) | HMGCR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5506219-A | ANTICHOLESTEROL AND ANTILIPEMIC AGENTS | E. R. SQUIBB & SONS, INC. (US) | 1996-04-09 | — | — | US | disclosed |
| EP-0444533-A2 | Quinoline and pyridine anchors for HMG-CoA reductase inhibitors | E.R. SQUIBB & SONS, INC. (US) | 1991-09-04 | — | — | EP | disclosed |