Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HMGCR | P04035 | 4/20 | 0.42 |
| ▸ | GCGR | P47871 | 1/20 | 0.36 |
| ▸ | CTSA | P10619 | 1/20 | 0.33 |
| ▸ | DHODH | Q02127 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9849132 | 0.89 | HMGCR (0.36) | HMGCRCTSADHODH | |
| SCHEMBL8876495 | 0.86 | HMGCR (0.54) | HMGCRGCGR | |
| SCHEMBL8877862 | 0.85 | HMGCR (0.44) | HMGCRDHODH | |
| SCHEMBL8878764 | 0.79 | HMGCR (0.44) | HMGCRGCGR | |
| SCHEMBL8877555 | 0.78 | HMGCR (0.48) | HMGCRGCGR | |
| SCHEMBL8877954 | 0.78 | DHODH (0.43) | HMGCRCTSADHODH | |
| SCHEMBL8878729 | 0.76 | SQOR (0.39) | HMGCR | |
| SCHEMBL8952918 | 0.76 | HMGCR (0.43) | HMGCRGCGR | |
| SCHEMBL8878236 | 0.76 | HMGCR (0.43) | HMGCRGCGR | |
| SCHEMBL8877967 | 0.75 | HMGCR (0.52) | HMGCRGCGR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5691322-A | Quinoline and pyridine anchors for HMG-CoA reductase inhibitors | E.R. SQUIBB & SONS, INC. (US) | 1997-11-25 | — | — | US | disclosed |
| US-5686433-A | CHOLESTEROL BIOSYNTHESIS INHIBITION | E.R. SQUIBB & SONS, INC. (US) | 1997-11-11 | — | — | US | disclosed |
| US-5506219-A | ANTICHOLESTEROL AND ANTILIPEMIC AGENTS | E. R. SQUIBB & SONS, INC. (US) | 1996-04-09 | — | — | US | disclosed |