Known targets — ChEMBL curated mechanism
ADRB1ADRB2ATP4AATP4BAXLCHRM2CHRM3DRD2FLT3HRH1HTR2AHTR2BHTR2CKCNH2KMT2AMAP2K1MAP2K2MEN1MLNRPLK4RENS1PR1SLC6A2SLC6A4atpAatpBatpCatpDatpEatpFatpFHatpGpol
The experimentally established mechanism targets of Fumaric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 known ✓ | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A known ✓ | Q03164 | 1/20 | 0.38 |
| ▸ | HCAR2 | Q8TDS4 | 6/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.42 |
| ▸ | TSHR | P16473 | 3/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | GLO1 | Q04760 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | SOAT1 | P35610 | 1/20 | 0.38 |
| ▸ | EGLN1 | Q9GZT9 | 2/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | EGLN3 | Q9H6Z9 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Maleic Acid SCHEMBL8953139 | 1.00 | HCAR2 (0.55) | HCAR2ALDH1A1TSHRMAPTNPSR1 | |
| Acrylic Acid SCHEMBL27670115 | 0.88 | ALDH1A1 (0.42) | HCAR2ALDH1A1TSHRMAPTNPSR1 | |
| SCHEMBL35720 | 0.87 | — | — | |
| Oxalic Acid SCHEMBL8924689 | 0.85 | ALDH1A1 (0.47) | HCAR2ALDH1A1TSHRMAPTNPSR1 | |
| Maleic Acid SCHEMBL3692041 | 0.85 | HCAR2 (0.45) | HCAR2ALDH1A1TSHREGLN1TP53 | |
| Acetic Acid SCHEMBL29279683 | 0.85 | ALDH1A1 (0.47) | HCAR2ALDH1A1TSHRMAPTNPSR1 | |
| Propionic Acid SCHEMBL11418925 | 0.85 | ALDH1A1 (0.47) | HCAR2ALDH1A1TSHRMAPTNPSR1 | |
| Methyl Alcohol SCHEMBL29084611 | 0.85 | ALDH1A1 (0.50) | ALDH1A1TSHRMAPTNPSR1GLO1 | |
| SCHEMBL8823387 | 0.84 | HCAR2 (0.47) | HCAR2ALDH1A1TSHRMAPTNPSR1 | |
| SCHEMBL31613159 | 0.83 | ALDH1A1 (0.45) | HCAR2ALDH1A1TSHRMAPTNPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5529889-A | CONTAINING CYANINE COMPOUND | CANON KABUSHIKI KAISHA (JP) | 1996-06-25 | — | — | US | disclosed |
| EP-0559101-A1 | Heat-developable photosensitive material and image forming method which uses the same | CANON KABUSHIKI KAISHA (JP) | 1993-09-08 | — | — | EP | disclosed |