Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8954062 | 0.94 | TP53 (0.47) | TP53 | |
| SCHEMBL9472517 | 0.89 | ALDH1A1 (0.47) | TP53 | |
| SCHEMBL7054174 | 0.87 | TP53 (0.48) | TP53 | |
| SCHEMBL8954122 | 0.85 | TP53 (0.48) | TP53 | |
| SCHEMBL9272194 | 0.84 | TP53 (0.44) | TP53 | |
| SCHEMBL9473359 | 0.83 | TP53 (0.44) | TP53 | |
| SCHEMBL8954114 | 0.83 | TP53 (0.47) | TP53 | |
| SCHEMBL9472519 | 0.83 | TP53 (0.44) | TP53 | |
| Hydrochloric Acid SCHEMBL8954138 | 0.83 | TP53 (0.43) | TP53 | |
| SCHEMBL7060199 | 0.82 | TP53 (0.57) | TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5530017-A | CONGESTIVE HEART FAILURE, RENAL FAILURE AND GLAUCOMA | SMITHKLINE BEECHAM CORP (US) | 1996-06-25 | — | — | US | disclosed |
| US-5444080-A | Hypotensive agents | SMITHKLINE BEECHAM CORPORATION (US) | 1995-08-22 | — | — | US | disclosed |
| US-5234917-A | Hypotensive agent, treatment of renal failure or glaucoma | SMITHKLINE BEECHAM CORPORATION | 1993-08-10 | — | — | US | disclosed |
| WO-1992002510-A1 | SUBSTITUTED [1H-IMIDAZOL-5-YL]ALKANOIC ACIDS | SMITHKLINE BEECHAM CORPORATION (US) | 1992-02-20 | — | — | WO | disclosed |
| EP-0437103-A2 | Substituted 5-(alkyl)carboxamide imidazoles | SMITHKLINE BEECHAM CORPORATION (US) | 1991-07-17 | — | — | EP | disclosed |