SCHEMBL8954292

SCHEMBL8954292

O=C(O)Cc1c(Cl)nc(-c2ccccc2)n1Cc1ccccc1

nearest known ligand 0.60

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 6/20 0.49
LMNA P02545 2/20 0.49
SMN1; SMN2 Q16637 2/20 0.49
RECQL P46063 1/20 0.49
RAB9A P51151 1/20 0.49
PDE6D O43924 2/20 0.49
ALDH2 P05091 1/20 0.49
ALDH3A1 P30838 1/20 0.49
AGTR1 P30556 1/20 0.47
AGTR2 P50052 1/20 0.47
BCL2 P10415 1/20 0.47
MCL1 Q07820 1/20 0.47
KDM4E B2RXH2 2/20 0.46
HPGD P15428 1/20 0.46
HSD17B10 Q99714 1/20 0.43
PTGDR2 Q9Y5Y4 1/20 0.42
MEN1 O00255 1/20 0.42
KMT2A Q03164 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11090546 0.93 ALDH1A1 (0.54) ALDH1A1LMNASMN1; SMN2RECQLRAB9A
SCHEMBL11091674 0.92 TP53 (0.53) ALDH1A1LMNASMN1; SMN2RECQLRAB9A
SCHEMBL11092481 0.92 AGTR1 (0.46) ALDH1A1LMNASMN1; SMN2RECQLRAB9A
SCHEMBL11093449 0.92 ALDH1A1 (0.48) ALDH1A1LMNASMN1; SMN2RECQLRAB9A
SCHEMBL11164690 0.91 AGTR1 (0.46) ALDH1A1LMNASMN1; SMN2RECQLRAB9A
SCHEMBL6227119 0.91 ALDH1A1 (0.43) ALDH1A1LMNASMN1; SMN2RECQLRAB9A
SCHEMBL7054371 0.90 ALDH1A1 (0.48) ALDH1A1LMNASMN1; SMN2RECQLRAB9A
Hydrochloric Acid SCHEMBL5331525 0.90 AGTR1 (0.42) ALDH1A1LMNASMN1; SMN2RECQLRAB9A
SCHEMBL11092577 0.89 CASR (0.47) ALDH1A1LMNASMN1; SMN2RECQLRAB9A
SCHEMBL11094574 0.88 PTGDR2 (0.52) ALDH1A1LMNASMN1; SMN2RECQLRAB9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 23 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0005528-B1 IMIDAZOLE DERIVATIVES, THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS Takeda Chemical Industries, Ltd. (JP) 1983-03-23 EP claimed
US-4207324-A DIURETICS, HYPOTENSIVE AGENTS TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 1980-06-10 US claimed
EP-0005528-A2 Imidazole derivatives, their preparation and pharmaceutical compositions Takeda Chemical Industries, Ltd. (JP) 1979-11-28 EP claimed
JP-54148788-A None JP disclosed
US-7182934-B2 Ultrasonic contrast agents; aqueous suspension GE HEALTHCARE AS (NO) 2007-02-27 US disclosed
US-5565480-A ANGIOTENSIN II RECEPTOR ANTAGONIST; USEFUL IN REGULATING HYPERTENSION, TREATMENT OF CONGESTIVE HEART FAILURE, RENAL FAILURE AND GLUCOMA SMITHKLINE BEECHAM CORPORATION (US) 1996-10-15 US disclosed
US-5530017-A CONGESTIVE HEART FAILURE, RENAL FAILURE AND GLAUCOMA SMITHKLINE BEECHAM CORP (US) 1996-06-25 US disclosed
US-5444081-A Treatment of hypertension, congestive heart failure, renal failure, glaucoma SMITHKLINE BEECHAM CORP (US) 1995-08-22 US disclosed
US-5444080-A Hypotensive agents SMITHKLINE BEECHAM CORPORATION (US) 1995-08-22 US disclosed
EP-0427463-B1 Substituted N-(imidazolyl)alkyl alanine derivatives SMITHKLINE BEECHAM CORP (US) 1995-03-08 EP disclosed
US-5294631-A Substituted benzimidazoles useful as angiotension II receptor antagonists SMITHKLINE BEECHAM CORPORATION (US) 1994-03-15 US disclosed
WO-1992002510-A1 SUBSTITUTED [1H-IMIDAZOL-5-YL]ALKANOIC ACIDS SMITHKLINE BEECHAM CORPORATION (US) 1992-02-20 WO disclosed
WO-1992000068-A1 SUBSTITUTED HISTIDINES SMITHKLINE BEECHAM CORPORATION (US) 1992-01-09 WO disclosed
WO-1991016313-A1 SUBSTITUTED BENZIMIDAZOLES SMITHKLINE BEECHAM CORPORATION (US) 1991-10-31 WO disclosed
EP-0437103-A2 Substituted 5-(alkyl)carboxamide imidazoles SMITHKLINE BEECHAM CORPORATION (US) 1991-07-17 EP disclosed
EP-0427463-A1 Substituted N-(imidazolyl)alkyl alanine derivatives SMITHKLINE BEECHAM CORPORATION (US) 1991-05-15 EP disclosed
EP-0005528-B1 IMIDAZOLE DERIVATIVES, THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS Takeda Chemical Industries, Ltd. (JP) 1983-03-23 EP disclosed
US-4207324-A DIURETICS, HYPOTENSIVE AGENTS TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 1980-06-10 US disclosed
EP-0005528-A2 Imidazole derivatives, their preparation and pharmaceutical compositions Takeda Chemical Industries, Ltd. (JP) 1979-11-28 EP disclosed
JP-S54148788-A 1,2-DISUBSTITUTED-4-HALOGENOIMIDAZOLE-5-ACETIC ACID DERIVATIVE AND ITS PREPARATION TAKEDA CHEM IND LTD 1979-11-21 JP disclosed