Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CASR | P41180 | 1/20 | 0.47 |
| ▸ | BCL2 | P10415 | 1/20 | 0.44 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.42 |
| ▸ | AGTR2 | P50052 | 1/20 | 0.42 |
| ▸ | PLA2G2A | P14555 | 3/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.40 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.40 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | RECQL | P46063 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8954292 | 0.89 | ALDH1A1 (0.49) | BCL2MCL1ALDH1A1KDM4EHPGD | |
| SCHEMBL11092481 | 0.86 | AGTR1 (0.46) | BCL2MCL1TP53ALDH1A1KDM4E | |
| SCHEMBL11093449 | 0.86 | ALDH1A1 (0.48) | BCL2MCL1ALDH1A1KDM4EHPGD | |
| SCHEMBL11093981 | 0.84 | TLR7 (0.49) | ALDH1A1PLA2G2ALMNASMN1; SMN2 | |
| SCHEMBL11090546 | 0.83 | ALDH1A1 (0.54) | ALDH1A1KDM4EHPGDAGTR1AGTR2 | |
| SCHEMBL11091674 | 0.81 | TP53 (0.53) | TP53ALDH1A1AGTR1AGTR2LMNA | |
| SCHEMBL11098913 | 0.81 | CCR2 (0.50) | TP53ALDH1A1KDM4EHPGDPLA2G2A | |
| SCHEMBL6227119 | 0.81 | ALDH1A1 (0.43) | BCL2MCL1ALDH1A1AGTR1AGTR2 | |
| SCHEMBL11164690 | 0.81 | AGTR1 (0.46) | BCL2MCL1TP53ALDH1A1KDM4E | |
| SCHEMBL7048392 | 0.81 | AGTR1 (0.44) | BCL2MCL1TP53ALDH1A1AGTR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0028834-B1 | IMIDAZOLE-5-ACETIC ACID DERIVATIVES, THEIR PRODUCTION AND USE | Takeda Chemical Industries, Ltd. (JP) | 1984-01-18 | — | — | EP | disclosed |
| US-4355040-A | Hypotensive imidazole-5-acetic acid derivatives | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1982-10-19 | — | — | US | disclosed |