Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 9/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.57 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.57 |
| ▸ | DRD2 | P14416 | 1/20 | 0.55 |
| ▸ | DRD4 | P21917 | 1/20 | 0.55 |
| ▸ | LMNA | P02545 | 1/20 | 0.54 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.54 |
| ▸ | HTT | P42858 | 1/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.54 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.54 |
| ▸ | WDR5 | P61964 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5825855 | 0.93 | KMT2A (0.60) | HRH3KMT2ACYP2D6DRD2DRD4 | |
| SCHEMBL2096611 | 0.87 | KMT2A (0.62) | HRH3KMT2ACYP2D6DRD2DRD4 | |
| SCHEMBL8928364 | 0.87 | PRSS1 (0.55) | — | |
| SCHEMBL8928374 | 0.85 | PRSS1 (0.53) | — | |
| SCHEMBL9774806 | 0.83 | DRD2 (0.60) | HRH3KMT2ACYP2D6DRD2DRD4 | |
| SCHEMBL9808215 | 0.82 | LMNA (0.67) | HRH3KMT2ACYP2D6DRD2DRD4 | |
| SCHEMBL10632624 | 0.82 | HRH3 (0.57) | HRH3KMT2ADRD2DRD4LMNA | |
| SCHEMBL8778541 | 0.82 | HRH3 (0.57) | HRH3KMT2ADRD2DRD4LMNA | |
| SCHEMBL28540629 | 0.82 | HRH3 (0.57) | HRH3KMT2ADRD2DRD4LMNA | |
| SCHEMBL8035908 | 0.82 | HRH3 (0.57) | HRH3KMT2ADRD2DRD4LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5516767-A | PRODRUG AS HYPOGLYCEMIC AGENT | SANDOZ LTD. (CH) | 1996-05-14 | — | — | US | disclosed |
| US-5412137-A | Hypoglycemic agents | SANDOZ LTD. (CH) | 1995-05-02 | — | — | US | disclosed |