Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.41 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.41 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.38 |
| ▸ | FPR2 | P25090 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.37 |
| ▸ | NOS1 | P29475 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 4/20 | 0.36 |
| ▸ | MAPT | P10636 | 4/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.36 |
| ▸ | NPC1 | O15118 | 2/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.35 |
| ▸ | CA12 | O43570 | 2/20 | 0.35 |
| ▸ | CA1 | P00915 | 2/20 | 0.35 |
| ▸ | CA2 | P00918 | 2/20 | 0.35 |
| ▸ | CA9 | Q16790 | 2/20 | 0.35 |
| ▸ | CA14 | Q9ULX7 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL9725667 | 0.83 | ALDH1A1 (0.43) | HSD17B10GABRA5GABRB2ALDH1A1KDM4E | |
| SCHEMBL22190025 | 0.74 | CDK5 (0.54) | ALDH1A1KDM4ESMN1; SMN2MEN1MAPT | |
| SCHEMBL22190034 | 0.73 | CDK5 (0.41) | LMNA | |
| SCHEMBL27851069 | 0.73 | HSD17B10 (0.47) | HSD17B10GABRA5GABRB2ALDH1A1KDM4E | |
| SCHEMBL1565803 | 0.72 | HSD17B10 (0.46) | HSD17B10GABRA5GABRB2ALDH1A1KDM4E | |
| SCHEMBL2642609 | 0.72 | PIK3CG (0.53) | HSD17B10GABRA5GABRB2ALDH1A1KDM4E | |
| Hydrochloric Acid SCHEMBL1758691 | 0.70 | HSD17B10 (0.44) | HSD17B10GABRA5GABRB2ALDH1A1KDM4E | |
| SCHEMBL10537469 | 0.70 | GABRA5 (0.44) | HSD17B10GABRA5GABRB2ALDH1A1KDM4E | |
| SCHEMBL22190003 | 0.70 | PDE10A (0.50) | HSD17B10ALDH1A1KDM4ESMN1; SMN2MAPT | |
| SCHEMBL31494704 | 0.70 | AKR1B1 (0.36) | HSD17B10ALDH1A1SCN9AFPR2CA12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0581899-A4 | IMPROVED PROCESS FOR THE PREPARATION OF 1S-(1R*, 2S*, 3R*))-N-(4-(MORPHOLINYLSULFONYL)-L-PHENYLALANYL-3-(2-AMINO-4-THIAZOLYL)-N- (1-CYCLOHEXYLMETHYL)-2,3-DIHYDROXY-5-METHYLHEXYL)-L-ALANINAMIDE | WARNER LAMBERT CO (US) | 1996-10-02 | — | — | EP | disclosed |
| EP-0581899-A1 | IMPROVED PROCESS FOR THE PREPARATION OF 1S-(1R*, 2S*, 3R*)]-N-(4-(MORPHOLINYLSULFONYL)-L-PHENYLALANYL-3-(2-AMINO-4-THIAZOLYL)-N- (1-CYCLOHEXYLMETHYL)-2,3-DIHYDROXY-5-METHYLHEXYL]-L-ALANINAMIDE | WARNER-LAMBERT COMPANY (US) | 1994-02-09 | — | — | EP | disclosed |
| EP-0581899-A1 | IMPROVED PROCESS FOR THE PREPARATION OF 1S-(1R*, 2S*, 3R*)]-N-(4-(MORPHOLINYLSULFONYL)-L-PHENYLALANYL-3-(2-AMINO-4-THIAZOLYL)-N- (1-CYCLOHEXYLMETHYL)-2,3-DIHYDROXY-5-METHYLHEXYL]-L-ALANINAMIDE | WARNER-LAMBERT COMPANY (US) | 1994-02-09 | — | — | EP | disclosed |
| US-5268483-A | Process for the preparation of an L-alanine compound | WARNER-LAMBERT COMPANY (US) | 1993-12-07 | — | — | US | disclosed |
| US-5268483-A | Process for the preparation of an L-alanine compound | WARNER-LAMBERT COMPANY (US) | 1993-12-07 | — | — | US | disclosed |
| US-5220031-A | Process for the preparation of [1S-(1R*,2S*3R*)]-N-(4-morpholinylsulfonyl)-L-phenylalanyl-3-(2-amino-4-thiazolyl-N-[(cyclohexylmethyl)-2,3-dihydroxy-5-methylhexyl]-L-alaninamide | WARNER-LAMBERT COMPANY (US) | 1993-06-15 | — | — | US | disclosed |
| US-5220031-A | Process for the preparation of [1S-(1R*,2S*3R*)]-N-(4-morpholinylsulfonyl)-L-phenylalanyl-3-(2-amino-4-thiazolyl-N-[(cyclohexylmethyl)-2,3-dihydroxy-5-methylhexyl]-L-alaninamide | WARNER-LAMBERT COMPANY (US) | 1993-06-15 | — | — | US | disclosed |
| WO-1992018486-A1 | IMPROVED PROCESS FOR THE PREPARATION OF [1S-(1R*, 2S*, 3R*)]-N-(4-(MORPHOLINYLSULFONYL)-L-PHENYLALANYL-3-(2-AMINO-4-THIAZOLYL)-N-[(1-CYCLOHEXYLMETHYL)-2,3-DIHYDROXY-5-METHYLHEXYL]-L-ALANINAMIDE | WARNER-LAMBERT COMPANY (US) | 1992-10-29 | — | — | WO | disclosed |
| WO-1992018486-A1 | IMPROVED PROCESS FOR THE PREPARATION OF [1S-(1R*, 2S*, 3R*)]-N-(4-(MORPHOLINYLSULFONYL)-L-PHENYLALANYL-3-(2-AMINO-4-THIAZOLYL)-N-[(1-CYCLOHEXYLMETHYL)-2,3-DIHYDROXY-5-METHYLHEXYL]-L-ALANINAMIDE | WARNER-LAMBERT COMPANY (US) | 1992-10-29 | — | — | WO | disclosed |
| US-5089616-A | Process for the preparation of [1S-(1R*,2S*,3R*)]-N-(4-morpholinylsulfonyl)-L-phenylalanyl-3-(2-amino-4-thiazolyl-N-[(1-cyclohexylmethyl)-2,3-dihydroxy-5-methylhexyl]-L-alaninamide | WARNER-LAMBERT COMPANY (US) | 1992-02-18 | — | — | US | disclosed |
| US-5089616-A | Process for the preparation of [1S-(1R*,2S*,3R*)]-N-(4-morpholinylsulfonyl)-L-phenylalanyl-3-(2-amino-4-thiazolyl-N-[(1-cyclohexylmethyl)-2,3-dihydroxy-5-methylhexyl]-L-alaninamide | WARNER-LAMBERT COMPANY (US) | 1992-02-18 | — | — | US | disclosed |