Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC7A5 | Q01650 | 3/20 | 0.54 |
| ▸ | ALPI | P09923 | 1/20 | 0.54 |
| ▸ | PKM | P14618 | 1/20 | 0.54 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.54 |
| ▸ | XIAP | P98170 | 1/20 | 0.54 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | BRS3 | P32247 | 2/20 | 0.45 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.45 |
| ▸ | SLC1A3 | P43003 | 2/20 | 0.45 |
| ▸ | SLC1A2 | P43004 | 2/20 | 0.45 |
| ▸ | SLC1A1 | P43005 | 2/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | HPGDS | O60760 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10584263 | 0.80 | SLC7A5 (0.58) | SLC7A5ALPIPKMPTGS1XIAP | |
| SCHEMBL28526629 | 0.79 | SLC7A5 (0.47) | SLC7A5ALPIPKMPTGS1XIAP | |
| SCHEMBL28938740 | 0.79 | SLC7A5 (0.47) | SLC7A5ALPIPKMPTGS1XIAP | |
| SCHEMBL27446953 | 0.79 | SLC7A5 (0.51) | SLC7A5ALPIPKMPTGS1XIAP | |
| SCHEMBL29356218 | 0.79 | SLC7A5 (0.51) | SLC7A5ALPIPKMPTGS1XIAP | |
| SCHEMBL7345076 | 0.79 | BRS3 (0.49) | BRS3AOC3HPGDS | |
| SCHEMBL849758 | 0.79 | SLC7A5 (0.51) | SLC7A5ALPIPKMPTGS1XIAP | |
| SCHEMBL9314265 | 0.78 | KEAP1 (0.50) | BRS3AOC3HSD17B10HPGDS | |
| SCHEMBL5292853 | 0.77 | SLC7A5 (0.53) | SLC7A5ALPIPKMPTGS1XIAP | |
| SCHEMBL1539194 | 0.77 | SLC7A5 (0.53) | SLC7A5ALPIPKMPTGS1XIAP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113924290-A | Thiohydrazinocarboxylic acid esters and their use | 范因斯坦医学研究院 | 2022-01-11 | — | — | CN | disclosed |
| US-5565480-A | ANGIOTENSIN II RECEPTOR ANTAGONIST; USEFUL IN REGULATING HYPERTENSION, TREATMENT OF CONGESTIVE HEART FAILURE, RENAL FAILURE AND GLUCOMA | SMITHKLINE BEECHAM CORPORATION (US) | 1996-10-15 | — | — | US | disclosed |
| EP-0536262-A4 | SUBSTITUTED HISTIDINES | SMITHKLINE BEECHAM CORP (US) | 1996-08-14 | — | — | EP | disclosed |
| US-5444081-A | Treatment of hypertension, congestive heart failure, renal failure, glaucoma | SMITHKLINE BEECHAM CORP (US) | 1995-08-22 | — | — | US | disclosed |
| EP-0536262-A1 | SUBSTITUTED HISTIDINES | SMITHKLINE BEECHAM CORPORATION (US) | 1993-04-14 | — | — | EP | disclosed |
| WO-1992000068-A1 | SUBSTITUTED HISTIDINES | SMITHKLINE BEECHAM CORPORATION (US) | 1992-01-09 | — | — | WO | disclosed |