Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Nitric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA5A | P35218 | 1/20 | 0.40 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.39 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.35 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.35 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.35 |
| ▸ | GSR | P00390 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Nitric Acid SCHEMBL8957432 | 1.00 | CA5A (0.40) | CA5ACA5BTDP1PABPC1APOBEC3A | |
| SCHEMBL12606783 | 0.84 | TDP1 (0.35) | TDP1PABPC1APOBEC3AAPOBEC3GGSR | |
| SCHEMBL12606786 | 0.84 | TDP1 (0.35) | TDP1PABPC1APOBEC3AAPOBEC3GGSR | |
| SCHEMBL44781 | 0.81 | TDP1 (0.50) | TDP1PABPC1APOBEC3AAPOBEC3GALDH1A1 | |
| SCHEMBL130805 | 0.81 | TDP1 (0.50) | TDP1PABPC1APOBEC3AAPOBEC3GALDH1A1 | |
| SCHEMBL12816270 | 0.81 | TDP1 (0.50) | TDP1PABPC1APOBEC3AAPOBEC3GALDH1A1 | |
| SCHEMBL33424 | 0.81 | TDP1 (0.50) | TDP1PABPC1APOBEC3AAPOBEC3GALDH1A1 | |
| SCHEMBL130804 | 0.81 | TDP1 (0.50) | TDP1PABPC1APOBEC3AAPOBEC3GALDH1A1 | |
| SCHEMBL129425 | 0.81 | TDP1 (0.50) | TDP1PABPC1APOBEC3AAPOBEC3GALDH1A1 | |
| SCHEMBL12606821 | 0.79 | TDP1 (0.32) | TDP1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0689435-A1 | USE OF SUBSTITUTED ALKYL NITRATES FOR THE TREATMENT OF PATHOLOGICALLY INCREASED INTRA-OCULAR PRESSURE | BYK NEDERLAND BV (NL) | 1996-01-03 | — | — | EP | disclosed |
| WO-1994021248-A1 | USE OF SUBSTITUTED ALKYL NITRATES FOR THE TREATMENT OF PATHOLOGICALLY INCREASED INTRA-OCULAR PRESSURE | BYK NEDERLAND BV (NL) | 1994-09-29 | — | — | WO | disclosed |