Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM2 | Q14416 | 1/20 | 0.51 |
| ▸ | GRM3 | Q14832 | 1/20 | 0.51 |
| ▸ | ARG1 | P05089 | 1/20 | 0.39 |
| ▸ | ARG2 | P78540 | 1/20 | 0.39 |
| ▸ | GGT1 | P19440 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | SLC1A3 | P43003 | 2/20 | 0.35 |
| ▸ | SLC1A2 | P43004 | 2/20 | 0.35 |
| ▸ | SLC1A1 | P43005 | 2/20 | 0.35 |
| ▸ | CTSS | P25774 | 1/20 | 0.35 |
| ▸ | CTSK | P43235 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | BLM | P54132 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | THRA | P10827 | 1/20 | 0.34 |
| ▸ | THRB | P10828 | 1/20 | 0.34 |
| ▸ | METAP1 | P53582 | 1/20 | 0.34 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3614328 | 1.00 | GRM2 (0.51) | GRM2GRM3ARG1ARG2GGT1 | |
| SCHEMBL3614325 | 1.00 | GRM2 (0.51) | GRM2GRM3ARG1ARG2GGT1 | |
| SCHEMBL28773150 | 0.98 | GRM2 (0.49) | GRM2GRM3ARG1ARG2GGT1 | |
| SCHEMBL1814400 | 0.98 | GRM2 (0.49) | GRM2GRM3ARG1ARG2GGT1 | |
| SCHEMBL1815679 | 0.94 | GRM2 (0.45) | GRM2GRM3ARG1ARG2GGT1 | |
| SCHEMBL27699325 | 0.94 | GRM2 (0.45) | GRM2GRM3ARG1ARG2GGT1 | |
| SCHEMBL25660659 | 0.90 | ARG1 (0.42) | GRM2GRM3ARG1ARG2GGT1 | |
| SCHEMBL8233826 | 0.84 | GRM2 (0.44) | GRM2GRM3CYP2D6ALOX5HPGD | |
| SCHEMBL24520311 | 0.82 | ARG1 (0.38) | GRM2GRM3ARG1ARG2GGT1 | |
| SCHEMBL27620522 | 0.82 | GGT1 (0.46) | GRM2GRM3ARG1ARG2GGT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5559233-A | 3-/P-PHENYLBENZYL/IMIDAZOLONES AND PYRIMIDONES | SANOFI (FR) | 1996-09-24 | — | — | US | disclosed |
| US-5352788-A | Angiotensin antagonist | ELF SANOFI (FR) | 1994-10-04 | — | — | US | disclosed |
| US-5270317-A | N-substituted heterocyclic derivatives, their preparation and the pharmaceutical compositions in which they are present | ELF SANOFI (FR) | 1993-12-14 | — | — | US | disclosed |