Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.40 |
| ▸ | HPGD | P15428 | 3/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | MMP1 | P03956 | 1/20 | 0.34 |
| ▸ | MMP2 | P08253 | 1/20 | 0.34 |
| ▸ | MMP3 | P08254 | 1/20 | 0.34 |
| ▸ | MMP9 | P14780 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8957825 | 0.98 | L3MBTL1 (0.45) | L3MBTL1MEN1KMT2ATDP1ATM | |
| SCHEMBL6624121 | 0.79 | KMT2A (0.31) | KMT2AALDH1A1KDM4E | |
| SCHEMBL13448457 | 0.79 | HTT (0.52) | L3MBTL1MEN1KMT2AALDH1A1HPGD | |
| SCHEMBL23553150 | 0.78 | ALDH1A1 (0.52) | MEN1KMT2AALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL11286822 | 0.77 | ATM (0.42) | L3MBTL1MEN1KMT2ATDP1ATM | |
| SCHEMBL22691652 | 0.76 | L3MBTL1 (0.41) | L3MBTL1MEN1KMT2ATDP1ATM | |
| SCHEMBL14126452 | 0.76 | ATM (0.38) | L3MBTL1MEN1KMT2ATDP1ATM | |
| SCHEMBL22691649 | 0.76 | L3MBTL1 (0.41) | L3MBTL1MEN1KMT2ATDP1ATM | |
| SCHEMBL3184467 | 0.76 | CA2 (0.41) | L3MBTL1TDP1ATMALDH1A1SMN1; SMN2 | |
| SCHEMBL16391166 | 0.76 | EPHX2 (0.33) | MEN1KMT2ATDP1ALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010025436-A2 | NITROGEN AND SULFUR-CONTAINING HETEROCYCLE DERIVATIVES | TRIAD MULTITECH PHARMACEUTICALS, INC. (US) | 2010-03-04 | — | — | WO | disclosed |
| EP-0469889-B1 | (p-Carbonylaminophenyl)-sulphonyl-nitromethane derivatives | ZENECA LTD (GB) | 1996-01-17 | — | — | EP | disclosed |
| US-5189031-A | Inhibitor of enzyme aldose reductase, useful in the treatment of certain peripheral effects of diabetes and galactosemia | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1993-02-23 | — | — | US | disclosed |
| US-5110808-A | Aldose reductase inhibitors; peripheral effects of diabetes and galactosemia | IMPERIAL CHEMICAL INDUSTRIES, PLC (GB) | 1992-05-05 | — | — | US | disclosed |
| EP-0469889-A1 | (p-Carbonylaminophenyl)-sulphonyl-nitromethane derivatives | ZENECA LIMITED (GB) | 1992-02-05 | — | — | EP | disclosed |