Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.32 |
| ▸ | FFAR3 | O14843 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5686235 | 0.79 | TDP1 (0.32) | TDP1FFAR3ALDH1A1 | |
| SCHEMBL10871210 | 0.76 | P2RX4 (0.33) | ALDH1A1 | |
| SCHEMBL19388378 | 0.73 | — | — | |
| SCHEMBL4146905 | 0.72 | ALDH1A1 (0.37) | TDP1FFAR3ALDH1A1 | |
| SCHEMBL2321266 | 0.69 | — | — | |
| SCHEMBL584108 | 0.69 | TP53 (0.35) | — | |
| SCHEMBL11986377 | 0.69 | — | — | |
| SCHEMBL8958094 | 0.69 | ALDH1A1 (0.40) | ALDH1A1 | |
| SCHEMBL8958069 | 0.67 | ALDH1A1 (0.33) | ALDH1A1 | |
| SCHEMBL7078801 | 0.67 | ALOX5 (0.34) | TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0469889-B1 | (p-Carbonylaminophenyl)-sulphonyl-nitromethane derivatives | ZENECA LTD (GB) | 1996-01-17 | — | — | EP | disclosed |
| US-5189031-A | Inhibitor of enzyme aldose reductase, useful in the treatment of certain peripheral effects of diabetes and galactosemia | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1993-02-23 | — | — | US | disclosed |
| US-5110808-A | Aldose reductase inhibitors; peripheral effects of diabetes and galactosemia | IMPERIAL CHEMICAL INDUSTRIES, PLC (GB) | 1992-05-05 | — | — | US | disclosed |
| EP-0469889-A1 | (p-Carbonylaminophenyl)-sulphonyl-nitromethane derivatives | ZENECA LIMITED (GB) | 1992-02-05 | — | — | EP | disclosed |