Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 10/20 | 0.38 |
| ▸ | HSD11B1 | P28845 | 5/20 | 0.35 |
| ▸ | CTSD | P07339 | 2/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | PDE4A | P27815 | 1/20 | 0.31 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.31 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.31 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.31 |
| ▸ | MMP1 | P03956 | 1/20 | 0.31 |
| ▸ | MMP3 | P08254 | 1/20 | 0.31 |
| ▸ | MMP9 | P14780 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8958105 | 1.00 | BACE1 (0.38) | BACE1HSD11B1CTSDCYP1A2LMNA | |
| SCHEMBL8958111 | 1.00 | BACE1 (0.38) | BACE1HSD11B1CTSDCYP1A2LMNA | |
| SCHEMBL8958243 | 0.77 | BACE1 (0.34) | BACE1HSD11B1GAA | |
| SCHEMBL8958239 | 0.77 | BACE1 (0.34) | BACE1HSD11B1GAA | |
| SCHEMBL8958235 | 0.77 | BACE1 (0.34) | BACE1HSD11B1GAA | |
| SCHEMBL8958290 | 0.73 | BACE1 (0.33) | BACE1HSD11B1GAA | |
| SCHEMBL8958277 | 0.73 | BACE1 (0.33) | BACE1HSD11B1GAA | |
| SCHEMBL8958282 | 0.73 | BACE1 (0.33) | BACE1HSD11B1GAA | |
| SCHEMBL26688941 | 0.70 | LMNA (0.31) | LMNA | |
| SCHEMBL3484547 | 0.70 | ALDH1A1 (0.34) | MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5559233-A | 3-/P-PHENYLBENZYL/IMIDAZOLONES AND PYRIMIDONES | SANOFI (FR) | 1996-09-24 | — | — | US | disclosed |
| US-5352788-A | Angiotensin antagonist | ELF SANOFI (FR) | 1994-10-04 | — | — | US | disclosed |
| US-5270317-A | N-substituted heterocyclic derivatives, their preparation and the pharmaceutical compositions in which they are present | ELF SANOFI (FR) | 1993-12-14 | — | — | US | disclosed |