Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 2/20 | 0.34 |
| ▸ | BACE2 | Q9Y5Z0 | 2/20 | 0.34 |
| ▸ | HSD11B1 | P28845 | 7/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | MMP13 | P45452 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
| ▸ | APP | P05067 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8958239 | 1.00 | BACE1 (0.34) | BACE1BACE2HSD11B1GAAMMP13 | |
| SCHEMBL8958243 | 1.00 | BACE1 (0.34) | BACE1BACE2HSD11B1GAAMMP13 | |
| SCHEMBL8958290 | 0.81 | BACE1 (0.33) | BACE1BACE2HSD11B1GAAMMP13 | |
| SCHEMBL8958282 | 0.81 | BACE1 (0.33) | BACE1BACE2HSD11B1GAAMMP13 | |
| SCHEMBL8958277 | 0.81 | BACE1 (0.33) | BACE1BACE2HSD11B1GAAMMP13 | |
| SCHEMBL8958101 | 0.77 | BACE1 (0.38) | BACE1HSD11B1GAA | |
| SCHEMBL8958111 | 0.77 | BACE1 (0.38) | BACE1HSD11B1GAA | |
| SCHEMBL8958105 | 0.77 | BACE1 (0.38) | BACE1HSD11B1GAA | |
| SCHEMBL3484547 | 0.72 | ALDH1A1 (0.34) | — | |
| SCHEMBL9263485 | 0.72 | ACHE (0.39) | GAATDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5559233-A | 3-/P-PHENYLBENZYL/IMIDAZOLONES AND PYRIMIDONES | SANOFI (FR) | 1996-09-24 | — | — | US | disclosed |
| US-5352788-A | Angiotensin antagonist | ELF SANOFI (FR) | 1994-10-04 | — | — | US | disclosed |
| US-5274104-A | N-substituted heterocyclic derivatives useful in the treatment of cardiovascular disorders | ELF SANOFI, A FRENCH CORP. (FR) | 1993-12-28 | — | — | US | disclosed |
| US-5270317-A | N-substituted heterocyclic derivatives, their preparation and the pharmaceutical compositions in which they are present | ELF SANOFI (FR) | 1993-12-14 | — | — | US | disclosed |
| US-5268375-A | Dinitrogen heterocyclic derivatives N-substituted by a biphenylmethyl group, and the pharmaceutical compositions in which they are present | ELF SANOFI (FR) | 1993-12-07 | — | — | US | disclosed |