Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 2/20 | 0.51 |
| ▸ | BDKRB1 | P46663 | 2/20 | 0.48 |
| ▸ | LTB4R2 | Q9NPC1 | 1/20 | 0.41 |
| ▸ | SCN9A | Q15858 | 6/20 | 0.41 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.41 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.41 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.41 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.41 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.38 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.38 |
| ▸ | BRS3 | P32247 | 1/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.38 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.37 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.37 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8958363 | 0.91 | BDKRB1 (0.46) | ACHEBDKRB1LTB4R2SCN9ACHRNB2 | |
| SCHEMBL9447504 | 0.86 | ACHE (0.49) | ACHEBDKRB1LTB4R2SLC6A3SLC6A4 | |
| SCHEMBL5782374 | 0.84 | BDKRB1 (0.60) | ACHEBDKRB1LTB4R2CHRNB2CHRNB4 | |
| SCHEMBL9032066 | 0.79 | GAA (0.48) | ACHEBDKRB1LTB4R2CHRNB2CHRNB4 | |
| SCHEMBL9030773 | 0.78 | CHRNB2 (0.45) | ACHEBDKRB1LTB4R2CHRNB2CHRNB4 | |
| SCHEMBL8958523 | 0.77 | BDKRB1 (0.49) | ACHEBDKRB1 | |
| SCHEMBL5782255 | 0.77 | BDKRB1 (0.66) | ACHEBDKRB1SLC6A3SLC6A4BRS3 | |
| SCHEMBL9030770 | 0.77 | IDO1 (0.50) | ACHEBDKRB1LTB4R2CHRNB2CHRNB4 | |
| SCHEMBL489306 | 0.76 | NR1H2 (0.48) | ACHELTB4R2SLC6A3SLC6A4BRS3 | |
| SCHEMBL8875151 | 0.76 | ACHE (0.48) | ACHELTB4R2SLC6A3SLC6A4BRS3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5559233-A | 3-/P-PHENYLBENZYL/IMIDAZOLONES AND PYRIMIDONES | SANOFI (FR) | 1996-09-24 | — | — | US | disclosed |
| US-5352788-A | Angiotensin antagonist | ELF SANOFI (FR) | 1994-10-04 | — | — | US | disclosed |
| US-5270317-A | N-substituted heterocyclic derivatives, their preparation and the pharmaceutical compositions in which they are present | ELF SANOFI (FR) | 1993-12-14 | — | — | US | disclosed |